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Fndc3c1 fibronectin type III domain containing 3C1 [ Mus musculus (house mouse) ]

Gene ID: 333564, updated on 28-Oct-2024

Summary

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Official Symbol
Fndc3c1provided by MGI
Official Full Name
fibronectin type III domain containing 3C1provided by MGI
Primary source
MGI:MGI:2685630
See related
Ensembl:ENSMUSG00000033737 AllianceGenome:MGI:2685630
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm784; Fndc3c
Summary
Predicted to be involved in spermatid development. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in embryo; embryo endoderm; and extraembryonic ectoderm. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in CNS E11.5 (RPKM 9.0), limb E14.5 (RPKM 4.7) and 2 other tissues See more
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Genomic context

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See Fndc3c1 in Genome Data Viewer
Location:
X D; X 47.36 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105463647..105529436, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106420041..106485577, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 6382 Neighboring gene fibronectin type III domain containing 3C1 pseudogene Neighboring gene cysteinyl leukotriene receptor 1 Neighboring gene STARR-seq mESC enhancer starr_47737 Neighboring gene predicted gene, 24622 Neighboring gene predicted gene 5127 Neighboring gene predicted gene 14877

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FNDC3A is required for adhesion between spermatids and Sertoli cells. Obholz KL, et al. Dev Biol, 2006 Oct 15. PMID 16904100, Free PMC Article
  2. Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. Pearton DJ, et al. Dev Biol, 2014 Aug 15. PMID 24859262
  3. A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). Hou J, et al. BMC Dev Biol, 2007 Aug 2. PMID 17683524, Free PMC Article
  4. Transcriptional analysis of cleft palate in TGFβ3 mutant mice. Liu J, et al. Sci Rep, 2020 Sep 10. PMID 32913205, Free PMC Article
  5. The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Budry L, et al. Genes Dev, 2012 Oct 15. PMID 23070814, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC100196, MGC100347

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibronectin type III domain containing protein 3C1
Names
fibronectin domain-containing protein 3c
fibronectin type III domain containing protein 3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007580.1 → NP_001007581.1  fibronectin type III domain containing protein 3C1

    See identical proteins and their annotated locations for NP_001007581.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076625
    Consensus CDS
    CCDS30342.1
    UniProtKB/Swiss-Prot
    Q6DFV6
    Related
    ENSMUSP00000038678.8, ENSMUST00000039447.14
    Conserved Domains (3) summary
    PRK08581
    Location:271 → 509
    PRK08581; amidase domain-containing protein
    cd00063
    Location:1026 → 1100
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16656
    Location:460 → 546
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    105463647..105529436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247621.2 → XP_011245923.1  fibronectin type III domain containing protein 3C1 isoform X3

    Conserved Domains (3) summary
    PRK08581
    Location:271 → 509
    PRK08581; amidase domain-containing protein
    cd00063
    Location:988 → 1062
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16656
    Location:460 → 546
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

  2. XM_006528103.3 → XP_006528166.1  fibronectin type III domain containing protein 3C1 isoform X1

    See identical proteins and their annotated locations for XP_006528166.1

    UniProtKB/Swiss-Prot
    Q6DFV6
    Conserved Domains (3) summary
    PRK08581
    Location:271 → 509
    PRK08581; amidase domain-containing protein
    cd00063
    Location:1026 → 1100
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16656
    Location:460 → 546
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

  3. XM_006528104.5 → XP_006528167.1  fibronectin type III domain containing protein 3C1 isoform X1

    See identical proteins and their annotated locations for XP_006528167.1

    UniProtKB/Swiss-Prot
    Q6DFV6
    Conserved Domains (3) summary
    PRK08581
    Location:271 → 509
    PRK08581; amidase domain-containing protein
    cd00063
    Location:1026 → 1100
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16656
    Location:460 → 546
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

  4. XM_006528106.4 → XP_006528169.1  fibronectin type III domain containing protein 3C1 isoform X1

    See identical proteins and their annotated locations for XP_006528169.1

    UniProtKB/Swiss-Prot
    Q6DFV6
    Conserved Domains (3) summary
    PRK08581
    Location:271 → 509
    PRK08581; amidase domain-containing protein
    cd00063
    Location:1026 → 1100
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16656
    Location:460 → 546
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

  5. XM_011247620.3 → XP_011245922.1  fibronectin type III domain containing protein 3C1 isoform X2

    Conserved Domains (3) summary
    PRK08581
    Location:235 → 473
    PRK08581; amidase domain-containing protein
    cd00063
    Location:990 → 1064
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16656
    Location:424 → 510
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

  6. XM_017318527.2 → XP_017174016.1  fibronectin type III domain containing protein 3C1 isoform X1

    UniProtKB/Swiss-Prot
    Q6DFV6
    Conserved Domains (3) summary
    PRK08581
    Location:271 → 509
    PRK08581; amidase domain-containing protein
    cd00063
    Location:1026 → 1100
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16656
    Location:460 → 546
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFV6.1 GenPept UniProtKB/Swiss-Prot:Q6DFV6

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