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myh9a myosin, heavy chain 9a, non-muscle [ Danio rerio (zebrafish) ]

Gene ID: 333938, updated on 17-Sep-2024

Summary

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Official Symbol
myh9aprovided by ZNC
Official Full Name
myosin, heavy chain 9a, non-muscleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5870
See related
Ensembl:ENSDARG00000063295 AllianceGenome:ZFIN:ZDB-GENE-030131-5870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
myh9; myh9l2; fi22c04; fj85e11; zgc:66164; wu:fi22c04; wu:fj85e11; zgc:162029
Summary
Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within glomerular filtration and glomerulus development. Predicted to be part of myosin complex. Is expressed in several structures, including epidermis; nervous system; periderm; pronephric duct opening; and tail bud. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See myh9a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (7735806..7776609, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7578633..7619450, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene solute carrier family 25 member 38b Neighboring gene ribosomal protein SA Neighboring gene phospholipid phosphatase related 2b Neighboring gene paralemmin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Non-muscle myosin IIA is required for the development of the zebrafish glomerulus. Müller T, et al. Kidney Int, 2011 Nov. PMID 21849970
  2. Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells. van Loon AP, et al. Mol Biol Cell, 2021 Aug 1. PMID 34081537, Free PMC Article
  3. Simultaneous assessment of glomerular filtration and barrier function in live zebrafish. Kotb AM, et al. Am J Physiol Renal Physiol, 2014 Dec 15. PMID 25298528, Free PMC Article
  4. Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Huang Y, et al. Gene Expr Patterns, 2013 Oct. PMID 23665442
  5. Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis. Gutzman JH, et al. Dev Biol, 2015 Jan 1. PMID 25446029

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC66164, MGC162029

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glomerular basement membrane development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glomerular capillary formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glomerular filtration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within glomerular filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glomerulus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within podocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cortical granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin-9a
Names
myosin heavy chain IX
myosin, heavy chain 9, non-muscle, like-2
myosin, heavy polypeptide 9, non-muscle
myosin, heavy polypeptide 9a, non-muscle
zNMHC-IIA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098177.2 → NP_001091647.2  myosin-9a

    See identical proteins and their annotated locations for NP_001091647.2

    Status: VALIDATED

    Source sequence(s)
    CR925711
    UniProtKB/TrEMBL
    A0A8M1NEM1
    Related
    ENSDARP00000124366.1, ENSDART00000149823.2
    Conserved Domains (6) summary
    cd14932
    Location:93 → 768
    MYSc_Myh18; class II myosin heavy chain 18, motor domain
    pfam00063
    Location:81 → 768
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:845 → 1925
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:28 → 66
    Myosin_N; Myosin N-terminal SH3-like domain
    cl23717
    Location:1067 → 1101
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    cl24005
    Location:1777 → 1878
    DUF2570; Protein of unknown function (DUF2570)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    7735806..7776609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165695.5 → XP_005165752.1  myosin-9a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BCY6
    Conserved Domains (5) summary
    cl22853
    Location:93 → 761
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:81 → 761
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:838 → 1918
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:28 → 66
    Myosin_N; Myosin N-terminal SH3-like domain
    cl24005
    Location:1770 → 1871
    DUF2570; Protein of unknown function (DUF2570)

  2. XM_005165694.5 → XP_005165751.1  myosin-9a isoform X1

    See identical proteins and their annotated locations for XP_005165751.1

    UniProtKB/TrEMBL
    A0A8M1NEM1
    Conserved Domains (6) summary
    cd14932
    Location:93 → 768
    MYSc_Myh18; class II myosin heavy chain 18, motor domain
    pfam00063
    Location:81 → 768
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:845 → 1925
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:28 → 66
    Myosin_N; Myosin N-terminal SH3-like domain
    cl23717
    Location:1067 → 1101
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    cl24005
    Location:1777 → 1878
    DUF2570; Protein of unknown function (DUF2570)
Nucleotide Protein Strain
Heading Accession and Version

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