ndel1b nudE neurodevelopment protein 1-like 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndel1bprovided by ZNC
Official Full Name: nudE neurodevelopment protein 1-like 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5889
See related: Ensembl:ENSDARG00000104225 AllianceGenome:ZFIN:ZDB-GENE-030131-5889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi23c04; wu:fi23e06
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; microtubule cytoskeleton organization; and vesicle transport along microtubule. Predicted to be located in cytoplasm; microtubule; and spindle. Predicted to be part of kinesin complex. Predicted to be active in centrosome and kinetochore. Is expressed in brain; hindbrain neural plate; notochord; somite; and trunk. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (48584680..48612078, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (44439273..44466666, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ndel1b is expressed predominantly in the somites in developing zebrafish.
Title: Expression profiles of ndel1a and ndel1b, two orthologs of the NudE-Like gene, in the zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

AW154176 (e-PCR)
- UniSTS:205921

fi23c04.x1 (e-PCR)
- UniSTS:197063

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of chromosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic centrosome separation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear distribution protein nudE-like 1-B

Names: NudE-like protein 1b; nudE nuclear distribution gene E homolog like 1 B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201307.2 → NP_958464.1 nuclear distribution protein nudE-like 1-B

See identical proteins and their annotated locations for NP_958464.1

Status: VALIDATED

Source sequence(s)

BX682555

UniProtKB/Swiss-Prot

Q803Q2

UniProtKB/TrEMBL

B2GRS6

Related

ENSDARP00000140064.1, ENSDART00000169923.2

Conserved Domains (3) summary

pfam04880
Location:135 → 308

NUDE_C; NUDE protein, C-terminal conserved region

pfam15898
Location:91 → 177

PRKG1_interact; cGMP-dependent protein kinase interacting domain

cl23765
Location:37 → 136

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits