ampd3b adenosine monophosphate deaminase 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ampd3bprovided by ZNC
Official Full Name: adenosine monophosphate deaminase 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5929
See related: Ensembl:ENSDARG00000032469 AllianceGenome:ZFIN:ZDB-GENE-030131-5929
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ampd3; fi25h10; zgc:55390; wu:fi25h10
Summary: Predicted to enable AMP deaminase activity. Predicted to be involved in AMP metabolic process and IMP biosynthetic process. Predicted to act upstream of or within purine ribonucleoside monophosphate biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including epidermis; hematopoietic system; periderm; peripheral olfactory organ; and ventral mesoderm. Orthologous to human AMPD3 (adenosine monophosphate deaminase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (16762391..16796786, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (16773325..16806729, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fj28c05.y1 (e-PCR)
- UniSTS:198955

AW175504 (e-PCR)
- UniSTS:205770

fi25h10.x1 (e-PCR)
- UniSTS:204517

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables AMP deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMP deaminase activity	IEA Inferred from Electronic Annotation more info
enables deaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AMP deaminase 3b

Names: AMP deaminase 3; adenosine monophosphate deaminase 3

NP_956142.1

EC 3.5.4.6

XP_005159110.1

EC 3.5.4.6

XP_005159111.1

EC 3.5.4.6

XP_005159112.1

EC 3.5.4.6

XP_021323269.1

EC 3.5.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199848.1 → NP_956142.1 AMP deaminase 3b

See identical proteins and their annotated locations for NP_956142.1

Status: PROVISIONAL

Source sequence(s)

BC044154

UniProtKB/TrEMBL

Q803X5

Related

ENSDARP00000048721.6, ENSDART00000048722.8

Conserved Domains (2) summary

PLN03055
Location:157 → 765

PLN03055; AMP deaminase; Provisional

cl00281
Location:157 → 765

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

16762391..16796786 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467594.2 → XP_021323269.1 AMP deaminase 3b isoform X1

UniProtKB/TrEMBL

A0A8M2B5I2, Q1LYD7

Conserved Domains (1) summary

cl00281
Location:157 → 765

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_005159053.5 → XP_005159110.1 AMP deaminase 3b isoform X1

UniProtKB/TrEMBL

A0A8M2B5I2, Q1LYD7

Conserved Domains (1) summary

cl00281
Location:157 → 765

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_005159055.5 → XP_005159112.1 AMP deaminase 3b isoform X3

UniProtKB/TrEMBL

A0A8M2B601

Conserved Domains (2) summary

PLN03055
Location:137 → 745

PLN03055; AMP deaminase; Provisional

cl00281
Location:137 → 745

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_005159054.3 → XP_005159111.1 AMP deaminase 3b isoform X2

UniProtKB/TrEMBL

A0A8M2B614

Conserved Domains (2) summary

PLN03055
Location:145 → 753

PLN03055; AMP deaminase; Provisional

cl00281
Location:145 → 753

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...