pls1 plastin 1 (I isoform) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pls1provided by ZNC
Official Full Name: plastin 1 (I isoform)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6205
See related: Ensembl:ENSDARG00000039272 AllianceGenome:ZFIN:ZDB-GENE-030131-6205
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63494; wu:fi38g03
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Is expressed in macrophage; otic vesicle; pronephros; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (8060775..8112826, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (8262770..8314009, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW171287 (e-PCR)
- UniSTS:205837

fi38g03.x1 (e-PCR)
- UniSTS:197429

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plastin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199881.1 → NP_956175.1 plastin-1

See identical proteins and their annotated locations for NP_956175.1

Status: PROVISIONAL

Source sequence(s)

BC063742

UniProtKB/TrEMBL

Q6P406

Conserved Domains (4) summary

smart00033
Location:397 → 500

CH; Calponin homology domain

COG5069
Location:4 → 619

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:15 → 78

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00307
Location:122 → 231

CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

8060775..8112826 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479039.2 → XP_021334714.1 plastin-1 isoform X1

UniProtKB/TrEMBL

A0A8M9QBL9, F1QCE2

Related

ENSDARP00000109993.3, ENSDART00000123103.4

Conserved Domains (1) summary

COG5069
Location:35 → 656

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
XM_021479043.2 → XP_021334718.1 plastin-1 isoform X2

UniProtKB/TrEMBL

A0A8M9Q5A8, A5PM88, F1Q9Y7

Conserved Domains (1) summary

COG5069
Location:4 → 619

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
XM_068223101.1 → XP_068079202.1 plastin-1 isoform X2

Related

ENSDARP00000113948.2, ENSDART00000131955.4