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mark3a MAP/microtubule affinity-regulating kinase 3a [ Danio rerio (zebrafish) ]

Gene ID: 334300, updated on 28-Oct-2024

Summary

Official Symbol
mark3aprovided by ZNC
Official Full Name
MAP/microtubule affinity-regulating kinase 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6232
See related
Ensembl:ENSDARG00000019345 AllianceGenome:ZFIN:ZDB-GENE-030131-6232
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mark3; fi39g08; zgc:55693; wu:fi39g08; zgc:152848
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See mark3a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15580750..15668716)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15449660..15537724)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108192020 Neighboring gene uncharacterized LOC101882994 Neighboring gene creatine kinase, brain a Neighboring gene tRNA methyltransferase 61A Neighboring gene BCL2 associated athanogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC152848

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
MAP/microtubule affinity-regulating kinase 3a
Names
MAP/microtubule affinity-regulating kinase 3
NP_956179.1
XP_005156682.1
XP_005156683.1
XP_005156685.1
XP_005156686.1
XP_021336197.1
XP_021336198.1
XP_021336199.1
XP_068081029.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199885.1NP_956179.1  MAP/microtubule affinity-regulating kinase 3a

    See identical proteins and their annotated locations for NP_956179.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047179
    UniProtKB/TrEMBL
    Q802W0
    Related
    ENSDARP00000024907.6, ENSDART00000013525.8
    Conserved Domains (4) summary
    cd12196
    Location:623720
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:57308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:56308
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:326368
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    15580750..15668716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224928.1XP_068081029.1  MAP/microtubule affinity-regulating kinase 3a isoform X8

  2. XM_005156628.5XP_005156685.1  MAP/microtubule affinity-regulating kinase 3a isoform X4

    UniProtKB/TrEMBL
    A0A8M2B2R7
    Conserved Domains (3) summary
    smart00220
    Location:57308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:56308
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:326368
    UBA_like_SF; UBA domain-like superfamily
  3. XM_021480523.2XP_021336198.1  MAP/microtubule affinity-regulating kinase 3a isoform X6

    UniProtKB/TrEMBL
    A0A8M9Q9J6
    Conserved Domains (2) summary
    cd14072
    Location:56308
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:326368
    UBA_like_SF; UBA domain-like superfamily
  4. XM_021480522.2XP_021336197.1  MAP/microtubule affinity-regulating kinase 3a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PXN3
    Conserved Domains (3) summary
    cd12196
    Location:647744
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    cd14072
    Location:56308
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:326368
    UBA_like_SF; UBA domain-like superfamily
  5. XM_005156626.2XP_005156683.1  MAP/microtubule affinity-regulating kinase 3a isoform X3

    UniProtKB/TrEMBL
    A0A2R8QKT7, A0A8M2B2N9
    Related
    ENSDARP00000153634.1, ENSDART00000190067.1
    Conserved Domains (4) summary
    cd12196
    Location:632729
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:57308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:56308
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:326368
    UBA_like_SF; UBA domain-like superfamily
  6. XM_005156629.5XP_005156686.1  MAP/microtubule affinity-regulating kinase 3a isoform X5

    UniProtKB/TrEMBL
    A0A8M2B2Y7
    Conserved Domains (3) summary
    smart00220
    Location:57308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:56308
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:326368
    UBA_like_SF; UBA domain-like superfamily
  7. XM_021480524.2XP_021336199.1  MAP/microtubule affinity-regulating kinase 3a isoform X7

    UniProtKB/TrEMBL
    A0A8M9QF87
    Conserved Domains (2) summary
    cd14072
    Location:56308
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:326368
    UBA_like_SF; UBA domain-like superfamily
  8. XM_005156625.2XP_005156682.1  MAP/microtubule affinity-regulating kinase 3a isoform X2

    UniProtKB/TrEMBL
    A0A8M2B3D6, E9QEM6
    Related
    ENSDARP00000041292.8, ENSDART00000041293.8
    Conserved Domains (4) summary
    cd12196
    Location:638735
    MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    smart00220
    Location:57308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:56308
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:326368
    UBA_like_SF; UBA domain-like superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077459.1: Suppressed sequence

    Description
    NM_001077459.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript and protein.