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map4k5 mitogen-activated protein kinase kinase kinase kinase 5 [ Danio rerio (zebrafish) ]

Gene ID: 334565, updated on 2-Nov-2024

Summary

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Official Symbol
map4k5provided by ZNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6497
See related
Ensembl:ENSDARG00000039125 AllianceGenome:ZFIN:ZDB-GENE-030131-6497
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fl74c10; zgc:55719; zgc:55985; wu:fl74c10
Summary
Predicted to enable MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See map4k5 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36705591..36761454, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36579761..36648348, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene distal membrane arm assembly component 2 like Neighboring gene cyclin dependent kinase like 1 (CDC2 related kinase) Neighboring gene atlastin GTPase 1 Neighboring gene salvador family WW domain containing protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Fassier C, et al. Nat Neurosci, 2010 Nov. PMID 20935645
  2. Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90. Pfeiffer J, et al. Dev Biol, 2018 Apr 15. PMID 29477339
  3. Disruption of Trim9 function abrogates macrophage motility in vivo. Tokarz DA, et al. J Leukoc Biol, 2017 Dec. PMID 29021367, Free PMC Article
  4. A high level of liver-specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in transgenic zebrafish. Nguyen AT, et al. Dis Model Mech, 2011 Nov. PMID 21729876, Free PMC Article
  5. Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Liu Y, et al. Front Genet, 2020. PMID 32849832, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC55719

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 5
NP_956207.1
XP_005157034.1
XP_005157038.1
XP_009305737.1
XP_021336201.1
XP_021336202.1
XP_021336204.1
XP_021336205.1
XP_021336206.1
XP_068081030.1
XP_068081031.1
XP_068081032.1
XP_068081033.1
XP_068081034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199913.2 → NP_956207.1  mitogen-activated protein kinase kinase kinase kinase 5

    See identical proteins and their annotated locations for NP_956207.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055001
    UniProtKB/TrEMBL
    Q7ZUA2
    Related
    ENSDARP00000034684.6, ENSDART00000029824.8
    Conserved Domains (3) summary
    smart00036
    Location:544 → 858
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    36705591..36761454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224933.1 → XP_068081034.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X10

  2. XM_068224929.1 → XP_068081030.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X5

  3. XM_021480527.2 → XP_021336202.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q9K2
    Conserved Domains (2) summary
    smart00036
    Location:559 → 874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

  4. XM_068224932.1 → XP_068081033.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X10

  5. XM_068224931.1 → XP_068081032.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X9

  6. XM_005156981.5 → XP_005157038.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X8

    UniProtKB/TrEMBL
    A0A8M2B328
    Conserved Domains (3) summary
    smart00036
    Location:531 → 846
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

  7. XM_009307462.4 → XP_009305737.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X7

    UniProtKB/TrEMBL
    A0A8M3AZ98, B8A6G9
    Conserved Domains (3) summary
    smart00036
    Location:544 → 858
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

  8. XM_068224930.1 → XP_068081031.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X6

  9. XM_005156977.5 → XP_005157034.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X5

    UniProtKB/TrEMBL
    A0A8M2B3T3
    Conserved Domains (3) summary
    smart00036
    Location:546 → 861
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:20 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

  10. XM_021480531.2 → XP_021336206.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X4

    UniProtKB/TrEMBL
    A0A8M9QJK1
    Conserved Domains (2) summary
    smart00036
    Location:557 → 871
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

  11. XM_021480530.2 → XP_021336205.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QNA9
    Conserved Domains (2) summary
    smart00036
    Location:557 → 872
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

  12. XM_021480529.2 → XP_021336204.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QF91
    Conserved Domains (2) summary
    smart00036
    Location:559 → 873
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5

  13. XM_021480526.2 → XP_021336201.1  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q9K2
    Conserved Domains (2) summary
    smart00036
    Location:559 → 874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06646
    Location:10 → 277
    STKc_MAP4K5; Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5
Nucleotide Protein Strain
Heading Accession and Version

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