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ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b [ Danio rerio (zebrafish) ]

Gene ID: 335195, updated on 12-Sep-2024

Summary

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Official Symbol
ywhaqbprovided by ZNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7135
See related
Ensembl:ENSDARG00000023323 AllianceGenome:ZFIN:ZDB-GENE-030131-7135
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ywhaz; ywhaq1; zgc:55499; wu:fa91b01; wu:fb02e12; wu:fb36f06; wu:fk86h02
Summary
Predicted to enable monooxygenase activity. Predicted to be involved in cellular protein localization and signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including nervous system; optic vesicle; pleuroperitoneal region; solid lens vesicle; and tail bud. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to several human genes including YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ywhaqb in Genome Data Viewer
Location:
chromosome: 17
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (32500452..32525649)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (32547941..32573138)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488118 Neighboring gene Kruppel like factor 11b Neighboring gene grainyhead-like transcription factor 1 Neighboring gene GC-rich sequence DNA-binding factor 2 Neighboring gene uncharacterized LOC108179784

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comprehensive Analysis of Neurotoxin-Induced Ablation of Dopaminergic Neurons in Zebrafish Larvae. Kalyn M, et al. Biomedicines, 2019 Dec 28. PMID 31905670, Free PMC Article
  2. A triple-drug nanotherapy to target breast cancer cells, cancer stem cells, and tumor vasculature. El-Sahli S, et al. Cell Death Dis, 2021 Jan 4. PMID 33414428, Free PMC Article
  3. Assessment of toxicity and genotoxicity of low doses of 5-fluorouracil in zebrafish (Danio rerio) two-generation study. Kovács R, et al. Water Res, 2015 Jun 15. PMID 25889180
  4. Validation of zebrafish (Danio rerio) reference genes for quantitative real-time RT-PCR normalization. Tang R, et al. Acta Biochim Biophys Sin (Shanghai), 2007 May. PMID 17492136, Free PMC Article
  5. Expression analysis of the family of 14-3-3 proteins in zebrafish development. Besser J, et al. Gene Expr Patterns, 2007 Feb. PMID 17127101

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b
Names
tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201484.1 → NP_958892.1  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b

    See identical proteins and their annotated locations for NP_958892.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044412
    UniProtKB/TrEMBL
    A0A2R8QKG9, F6P3J2, Q803M8
    Related
    ENSDARP00000022550.7, ENSDART00000018423.8
    Conserved Domains (1) summary
    cd10023
    Location:1 → 234
    14-3-3_theta; 14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    32500452..32525649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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