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syt4 synaptotagmin IV [ Danio rerio (zebrafish) ]

Gene ID: 335357, updated on 28-Oct-2024

Summary

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Official Symbol
syt4provided by ZNC
Official Full Name
synaptotagmin IVprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7297
See related
Ensembl:ENSDARG00000036505 AllianceGenome:ZFIN:ZDB-GENE-030131-7297
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73240; wu:fj05d11
Summary
Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and vesicle fusion. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; exocytic vesicle; and synapse. Is expressed in nervous system and neural tube. Orthologous to human SYT4 (synaptotagmin 4). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See syt4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (23907746..23916118)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (23636589..23644961)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene von Hippel-Lindau binding protein 1 Neighboring gene uncharacterized LOC101883418 Neighboring gene si:dkey-183c6.7 Neighboring gene si:dkey-183c6.8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rest represses maturation within migrating facial branchiomotor neurons. Love CE, et al. Dev Biol, 2015 May 15. PMID 25769695, Free PMC Article
  2. Expression and distribution of synaptotagmin family members in the zebrafish retina. Henry D, et al. J Comp Neurol, 2022 Mar. PMID 34468021, Free PMC Article
  3. Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b. Moravec CE, et al. J Neurosci, 2016 Sep 7. PMID 27605615, Free PMC Article
  4. CoRest1 regulates neurogenesis in a stage-dependent manner. Monestime CM, et al. Dev Dyn, 2019 Oct. PMID 31301200, Free PMC Article
  5. Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans. Craxton M. BMC Genomics, 2007 Jul 31. PMID 17672888, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptotagmin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199948.1 → NP_956242.1  synaptotagmin-4

    See identical proteins and their annotated locations for NP_956242.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059580
    UniProtKB/TrEMBL
    A0A8M1PDQ6, Q6PBU6
    Related
    ENSDARP00000045478.6, ENSDART00000045479.7
    Conserved Domains (2) summary
    cd08388
    Location:166 → 292
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:301 → 437
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    23907746..23916118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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