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klc1b kinesin light chain 1b [ Danio rerio (zebrafish) ]

Gene ID: 335499, updated on 28-Oct-2024

Summary

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Official Symbol
klc1bprovided by ZNC
Official Full Name
kinesin light chain 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7439
See related
AllianceGenome:ZFIN:ZDB-GENE-030131-7439
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Klc2; klc1; kns2; zgc:55666; zgc:77660; wu:fj17e04
Summary
Predicted to be located in cytoplasm and microtubule. Predicted to be part of kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Orthologous to human KLC1 (kinesin light chain 1). [provided by Alliance of Genome Resources, Oct 2024]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See klc1b in Genome Data Viewer
Location:
chromosome: 13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (51903588..52169179)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (51518774..51530158)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase A Neighboring gene zmp:0000000755 Neighboring gene LBH regulator of WNT signaling pathway Neighboring gene serum response factor b Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene protein tyrosine kinase 7b Neighboring gene solute carrier family 30 member 10 Neighboring gene lysocardiolipin acyltransferase 1 Neighboring gene kelch domain containing 3 Neighboring gene transmembrane protein 121 Neighboring gene neuronal PAS domain protein 4 like Neighboring gene uncharacterized LOC100331665 Neighboring gene L-threonine ammonia-lyase-like Neighboring gene serine/threonine-protein kinase 32C Neighboring gene uncharacterized LOC100535731 Neighboring gene transmembrane protein 254 Neighboring gene fibrillin-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2. Li S, et al. Dev Neurobiol, 2024 Jul. PMID 38830696
  2. Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Reischauer S, et al. Nature, 2016 Jul 14. PMID 27411634
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2.
    Title: Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC55666

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin light chain 1b
Names
kinesin 2
kinesin light chain 1
kinesin light chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199954.1 → NP_956248.1  kinesin light chain 1b

    See identical proteins and their annotated locations for NP_956248.1

    Status: PROVISIONAL

    Source sequence(s)
    BC063959
    UniProtKB/TrEMBL
    Q6P3K1, Q7ZVT4
    Conserved Domains (4) summary
    sd00006
    Location:294 → 322
    TPR; TPR repeat [structural motif]
    pfam13374
    Location:293 → 334
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:248 → 326
    TPR_12; Tetratricopeptide repeat
    cl00388
    Location:13 → 70
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    51903588..52169179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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