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ptpn6 protein tyrosine phosphatase non-receptor type 6 [ Danio rerio (zebrafish) ]

Gene ID: 335573, updated on 28-Oct-2024

Summary

Official Symbol
ptpn6provided by ZNC
Official Full Name
protein tyrosine phosphatase non-receptor type 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7513
See related
Ensembl:ENSDARG00000089043 AllianceGenome:ZFIN:ZDB-GENE-030131-7513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Hcph; SHP1; fj22f05; zgc:55501; wu:fj22f05
Summary
Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and phosphotyrosine residue binding activity. Acts upstream of or within several processes, including regulation of hematopoietic stem cell proliferation; regulation of leukocyte migration; and regulation of myeloid leukocyte differentiation. Predicted to be active in cytoplasm. Is expressed in blood island; gill; immune system; and liver. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See ptpn6 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31720071..31756859, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (31765417..31801756, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily member 5 Neighboring gene retinol binding protein 1a, cellular Neighboring gene chromodomain helicase DNA binding protein 4b Neighboring gene wingless-type MMTV integration site family, member 4b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 6
NP_956254.1
XP_009290703.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199960.1NP_956254.1  tyrosine-protein phosphatase non-receptor type 6

    See identical proteins and their annotated locations for NP_956254.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044414
    UniProtKB/TrEMBL
    Q803M6
    Related
    ENSDARP00000105983.2, ENSDART00000126617.4
    Conserved Domains (4) summary
    cd09931
    Location:109212
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:3101
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:246517
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:276517
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    31720071..31756859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292428.2XP_009290703.1  tyrosine-protein phosphatase non-receptor type 6 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Q2T0, A0A8M3AJ85
    Related
    ENSDARP00000148161.1, ENSDART00000185043.1
    Conserved Domains (4) summary
    cd09931
    Location:110213
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:4102
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:247518
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:277518
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394963.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    1278..21739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)