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optn optineurin [ Danio rerio (zebrafish) ]

Gene ID: 336159, updated on 2-Nov-2024

Summary

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Official Symbol
optnprovided by ZNC
Official Full Name
optineurinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8103
See related
Ensembl:ENSDARG00000002663 AllianceGenome:ZFIN:ZDB-GENE-030131-8103
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66386; zgc:77868; wu:fj52f04; si:ch211-240l19.3
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Acts upstream of or within axonogenesis; defense response to bacterium; and vesicle localization. Predicted to be located in autophagosome; perinuclear region of cytoplasm; and recycling endosome. Predicted to be active in Golgi apparatus and nucleus. Is expressed in several structures, including brain; eye; muscle; periocular mesenchyme; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See optn in Genome Data Viewer
Location:
chromosome: 4
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (8016457..8027320)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (8007822..8018689)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase 1Da Neighboring gene coiled-coil domain containing 3a Neighboring gene si:ch211-240l19.8 Neighboring gene si:ch211-240l19.7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish optineurin: genomic organization and transcription regulation. Silva IAL, et al. Genome, 2022 Oct 1. PMID 36037528
  2. Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis. Chew TS, et al. Dis Model Mech, 2015 Aug 1. PMID 26044960, Free PMC Article
  3. Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates. Korac J, et al. J Cell Sci, 2013 Jan 15. PMID 23178947, Free PMC Article
  4. Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum. Xie J, et al. Front Cell Infect Microbiol, 2023. PMID 38264729, Free PMC Article
  5. Identification of an Alu-repeat-mediated deletion of OPTN upstream region in a patient with a complex ocular phenotype. Schilter KF, et al. Mol Genet Genomic Med, 2015 Nov. PMID 26740941, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum.
    Title: Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum.
  2. Zebrafish optineurin: genomic organization and transcription regulation.
    Title: Zebrafish optineurin: genomic organization and transcription regulation.
  3. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics
    Title: Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC66386

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi ribbon formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
optineurin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100066.2 → NP_001093536.2  optineurin

    Status: PROVISIONAL

    Source sequence(s)
    BC063986
    UniProtKB/Swiss-Prot
    Q5RI56, Q6P3H5, Q7SXF4
    Related
    ENSDARP00000020714.9, ENSDART00000014036.11
    Conserved Domains (2) summary
    pfam11577
    Location:26 → 93
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:350 → 451
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    8016457..8027320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474935.2 → XP_021330610.1  optineurin isoform X1

    UniProtKB/Swiss-Prot
    Q5RI56, Q6P3H5, Q7SXF4
    UniProtKB/TrEMBL
    A0A8M9QAZ9
    Conserved Domains (3) summary
    pfam11577
    Location:26 → 93
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:366 → 451
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl25732
    Location:9 → 401
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021474936.2 → XP_021330611.1  optineurin isoform X2

    UniProtKB/Swiss-Prot
    Q5RI56, Q6P3H5, Q7SXF4
    UniProtKB/TrEMBL
    A0A8M9Q5S4
    Conserved Domains (3) summary
    pfam11577
    Location:26 → 93
    NEMO; NF-kappa-B essential modulator NEMO
    pfam16516
    Location:361 → 446
    CC2-LZ; Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
    cl25732
    Location:1 → 391
    SMC_N; RecF/RecN/SMC N terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394549.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    115128..125451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RI56.2 GenPept UniProtKB/Swiss-Prot:Q5RI56

Gene LinkOut

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