myl1 myosin, light chain 1, alkali; skeletal, fast [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myl1provided by ZNC
Official Full Name: myosin, light chain 1, alkali; skeletal, fastprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8109
See related: Ensembl:ENSDARG00000014196 AllianceGenome:ZFIN:ZDB-GENE-030131-8109
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj53a11; zgc:65785; zgc:77231; wu:fj53a11
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within skeletal muscle tissue development. Is expressed in adaxial cell; fin; musculature system; and somite. Orthologous to human MYL1 (myosin light chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (38994232..39005300, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (39184437..39195505, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knock down of myl1 in zebrafish resulted in abnormal morphology, disrupted muscle structure and impaired touch-evoked escape responses, thus confirming that skeletal muscle fast-twitch specific myosin ELC is critical for myofibre development and function.
Title: Bi-allelic mutations in MYL1 cause a severe congenital myopathy.
Myl1 was found to be expressed exclusively in cells in the fast-twitch pathway initiated at an early stage of fast fibre differentiation.
Title: Alkali-like myosin light chain-1 (myl1) is an early marker for differentiating fast muscle cells in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in contractile muscle fiber	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin light chain 1, skeletal muscle isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200000.1 → NP_956294.1 myosin light chain 1, skeletal muscle isoform

See identical proteins and their annotated locations for NP_956294.1

Status: PROVISIONAL

Source sequence(s)

BC059795

UniProtKB/Swiss-Prot

Q6P0G6

Related

ENSDARP00000004932.5, ENSDART00000014207.6

Conserved Domains (1) summary

COG5126
Location:43 → 189

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]