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napsa napsin A aspartic peptidase [ Danio rerio (zebrafish) ]

Gene ID: 336746, updated on 28-Oct-2024

Summary

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Official Symbol
napsaprovided by ZNC
Official Full Name
napsin A aspartic peptidaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8690
See related
Ensembl:ENSDARG00000009313 AllianceGenome:ZFIN:ZDB-GENE-030131-8690
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa94d12; zgc:63831; wu:fa94d12
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space and lysosome. Orthologous to human NAPSA (napsin A aspartic peptidase). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See napsa in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25121365..25133244)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (24990817..25002696)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene chondroadherin-like a Neighboring gene mitochondrial elongation factor 1 Neighboring gene si:ch211-256m1.8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation of an Enhancer-Trapping Vector for Insertional Mutagenesis in Zebrafish. Liu C, et al. PLoS One, 2015. PMID 26436547, Free PMC Article
  2. A novel uveitis model induced by lipopolysaccharide in zebrafish. Xiao X, et al. Front Immunol, 2022. PMID 36532084, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
napsin-A
NP_956325.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200031.1 → NP_956325.1  napsin-A precursor

    See identical proteins and their annotated locations for NP_956325.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056836
    UniProtKB/TrEMBL
    Q6PGT7
    Related
    ENSDARP00000012342.6, ENSDART00000025724.7
    Conserved Domains (3) summary
    cd05490
    Location:86 → 410
    Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases
    pfam00026
    Location:91 → 411
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:21 → 48
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    25121365..25133244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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