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med14 mediator complex subunit 14 [ Danio rerio (zebrafish) ]

Gene ID: 336923, updated on 12-Sep-2024

Summary

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Official Symbol
med14provided by ZNC
Official Full Name
mediator complex subunit 14provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8867
See related
Ensembl:ENSDARG00000009953 AllianceGenome:ZFIN:ZDB-GENE-030131-8867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
EXLM1; crsp2; crsp150; trap170; wu:fd21c05; wu:fk28h11
Summary
Predicted to enable transcription coregulator activity. Acts upstream of or within animal organ development; blood vessel morphogenesis; and stem cell population maintenance. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in head and trunk. Orthologous to human MED14 (mediator complex subunit 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See med14 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34397826..34424015)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (34588627..34614830)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101887113 Neighboring gene lysosomal associated membrane protein 1b Neighboring gene growth hormone regulated TBC protein 1b Neighboring gene si:ch211-218d20.15 Neighboring gene si:ch211-269e2.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency. Sertori R, et al. Front Immunol, 2022. PMID 35967429, Free PMC Article
  2. Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development. Dürr K, et al. Genetics, 2006 Oct. PMID 16582438, Free PMC Article
  3. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Jiang YJ, et al. Development, 1996 Dec. PMID 9007241
  4. An in vivo requirement for the mediator subunit med14 in the maintenance of stem cell populations. Burrows JT, et al. Stem Cell Reports, 2015 Apr 14. PMID 25772472, Free PMC Article
  5. Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest. Lou X, et al. BMC Dev Biol, 2015 Nov 9. PMID 26553192, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ventricular system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 14
Names
cofactor required for Sp1 transcriptional activation, subunit 2
log
logelei

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212765.2 → NP_997930.2  mediator of RNA polymerase II transcription subunit 14

    Status: VALIDATED

    Source sequence(s)
    BX294189
    UniProtKB/TrEMBL
    A0A8M1PFL7
    Conserved Domains (2) summary
    pfam08638
    Location:36 → 223
    Med14; Mediator complex subunit MED14
    pfam12316
    Location:962 → 1149
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    34397826..34424015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167821.5 → XP_005167878.1  mediator of RNA polymerase II transcription subunit 14 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BFA2, F1R9C9
    Related
    ENSDARP00000010465.7, ENSDART00000011304.9
    Conserved Domains (2) summary
    pfam08638
    Location:36 → 223
    Med14; Mediator complex subunit MED14
    pfam12316
    Location:962 → 1148
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

  2. XM_005167822.4 → XP_005167879.1  mediator of RNA polymerase II transcription subunit 14 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFA7, E9QDB5
    Related
    ENSDARP00000123079.1, ENSDART00000146314.2
    Conserved Domains (2) summary
    pfam08638
    Location:36 → 223
    Med14; Mediator complex subunit MED14
    pfam11235
    Location:987 → 1125
    Med25_SD1; Mediator complex subunit 25 synapsin 1
Nucleotide Protein
Heading Accession and Version

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