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tuba5 tubulin alpha 5 [ Danio rerio (zebrafish) ]

Gene ID: 337223, updated on 28-Oct-2024

Summary

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Official Symbol
tuba5provided by ZNC
Official Full Name
tubulin alpha 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9167
See related
Ensembl:ENSDARG00000042708 AllianceGenome:ZFIN:ZDB-GENE-030131-9167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tuba8l; fb02d10; zgc:85698; wu:fb02d10
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in brain. Orthologous to human TUBA5P (tubulin alpha 5, pseudogene). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See tuba5 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28345352..28349859, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28326213..28330720, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene leiomodin 1a (smooth muscle) Neighboring gene lysine demethylase 5Bb Neighboring gene kelch-like protein 12 Neighboring gene adiponectin receptor 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A cargo model of yolk syncytial nuclear migration during zebrafish epiboly. Fei Z, et al. Development, 2019 Jan 2. PMID 30509968
  2. The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium. Willoughby PM, et al. Elife, 2021 Mar 23. PMID 33755014, Free PMC Article
  3. Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. Gebriel M, et al. J Neurosci Res, 2014 Jan. PMID 24123299
  4. Matrix metalloproteinase-9 plays a role in protecting zebrafish from lethal infection with Listeria monocytogenes by enhancing macrophage migration. Shan Y, et al. Fish Shellfish Immunol, 2016 Jul. PMID 27068748
  5. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin alpha 5
Names
tubulin, alpha 8 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212772.1 → NP_997937.1  tubulin alpha 5

    See identical proteins and their annotated locations for NP_997937.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067582
    UniProtKB/TrEMBL
    Q6NWI0
    Related
    ENSDARP00000062670.4, ENSDART00000062671.6
    Conserved Domains (2) summary
    PTZ00335
    Location:1 → 449
    PTZ00335; tubulin alpha chain; Provisional
    cd02186
    Location:2 → 435
    alpha_tubulin; The alpha-tubulin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    28345352..28349859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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