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plcd1b phospholipase C, delta 1b [ Danio rerio (zebrafish) ]

Gene ID: 337489, updated on 2-Nov-2024

Summary

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Official Symbol
plcd1bprovided by ZNC
Official Full Name
phospholipase C, delta 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9435
See related
Ensembl:ENSDARG00000034080 AllianceGenome:ZFIN:ZDB-GENE-030131-9435
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Plcd1; fj78d10; zgc:55868; wu:fj78d10
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Predicted to be active in cytoplasm. Is expressed in lens; neuromast; and solid lens vesicle. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See plcd1b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (21387898..21438555, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21729836..21780430, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene hedgehog acyltransferase like, a Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b Neighboring gene microRNA 26a-2 Neighboring gene uncharacterized LOC108179685 Neighboring gene AFG3-like AAA ATPase 2 Neighboring gene inhibin subunit beta Ab

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Duplication of phospholipase C-delta gene family in fish genomes. Kim MS, et al. Genomics, 2008 Nov. PMID 18722520
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b
Names
DrPLC-delta 1B
NP_956362.1
XP_005163413.1
XP_068079275.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200068.1 → NP_956362.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b

    See identical proteins and their annotated locations for NP_956362.1

    Status: PROVISIONAL

    Source sequence(s)
    BC051157
    UniProtKB/TrEMBL
    Q7ZU40
    Related
    ENSDARP00000046097.6, ENSDART00000046098.9
    Conserved Domains (7) summary
    cd00275
    Location:620 → 745
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08629
    Location:291 → 587
    PI-PLCc_delta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta1
    PLN02228
    Location:209 → 741
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:21 → 136
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:25 → 127
    PH; PH domain
    pfam09279
    Location:210 → 291
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam14788
    Location:156 → 205
    EF-hand_10; EF hand

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    21387898..21438555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223174.1 → XP_068079275.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X2

  2. XM_005163356.5 → XP_005163413.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAJ8
    Conserved Domains (7) summary
    cd00275
    Location:643 → 768
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08629
    Location:314 → 610
    PI-PLCc_delta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta1
    PLN02228
    Location:232 → 764
    PLN02228; Phosphoinositide phospholipase C
    cd13363
    Location:44 → 159
    PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain
    pfam00169
    Location:48 → 150
    PH; PH domain
    pfam09279
    Location:233 → 314
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam14788
    Location:179 → 228
    EF-hand_10; EF hand
Nucleotide Protein Strain
Heading Accession and Version

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