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fam49ba family with sequence similarity 49 member Ba [ Danio rerio (zebrafish) ]

Gene ID: 337591, updated on 2-Nov-2024

Summary

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Official Symbol
fam49baprovided by ZNC
Official Full Name
family with sequence similarity 49 member Baprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9537
See related
Ensembl:ENSDARG00000020929 AllianceGenome:ZFIN:ZDB-GENE-030131-9537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fam49b; fj85c11; zgc:64118; wu:fj85c11
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in positive regulation of T cell activation. Predicted to act upstream of or within regulation of actin filament polymerization. Predicted to be located in membrane. Is expressed in epidermis; periderm; pharyngeal arch 3-7 skeleton; and pronephros. Orthologous to human CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See fam49ba in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (32215272..32262287, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (32232054..32279069, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100003868 Neighboring gene uncharacterized LOC137487932 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a Neighboring gene upstream binding transcription factor, like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC337591
Names
family with sequence similarity 49, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291713.1 → NP_001278642.1  uncharacterized protein LOC337591 isoform 2

    See identical proteins and their annotated locations for NP_001278642.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame alternate exons in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC053261, EB764522, EH541135
    UniProtKB/TrEMBL
    A0A8M1P645, Q7T343
    Related
    ENSDARP00000056620.4, ENSDART00000056621.6
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 251
    DUF1394; Protein of unknown function (DUF1394)

  2. NM_200070.3 → NP_956364.2  uncharacterized protein LOC337591 isoform 1

    See identical proteins and their annotated locations for NP_956364.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    DT055468, EB764522, EH507686, EH541135
    UniProtKB/TrEMBL
    A0A8N7UZY6, Q6TLE5
    Related
    ENSDARP00000039716.4, ENSDART00000039717.6
    Conserved Domains (1) summary
    pfam07159
    Location:18 → 320
    DUF1394; Protein of unknown function (DUF1394)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    32215272..32262287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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