krt18a.1 keratin 18a, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: krt18a.1provided by ZNC
Official Full Name: keratin 18a, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030411-6
See related: Ensembl:ENSDARG00000018404 AllianceGenome:ZFIN:ZDB-GENE-030411-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb83; dapk1; krt18; DreK18; sb:cb83; wu:fa13f02; wu:fb36b04
Summary: Predicted to enable structural molecule activity. Predicted to be involved in intermediate filament cytoskeleton organization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Is expressed in several structures, including EVL; cardiovascular system; head; periderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in liver cirrhosis and metabolic dysfunction-associated steatohepatitis. Orthologous to human KRT18 (keratin 18). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (10347856..10351753)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (10412886..10416783)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Keratin 8/18a.1 Expression Influences Embryonic Neural Crest Cell Dynamics and Contributes to Postnatal Corneal Regeneration in Zebrafish.
Title: Keratin 8/18a.1 Expression Influences Embryonic Neural Crest Cell Dynamics and Contributes to Postnatal Corneal Regeneration in Zebrafish.
Microtubules and motor proteins support zebrafish neuronal migration by directing cargo.
Title: Microtubules and motor proteins support zebrafish neuronal migration by directing cargo.
Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18.
Title: cDNA sequences of the authentic keratins 8 and 18 in zebrafish.
krt18 is maternally inherited and its tissue distribution is reported. Its expression is established during early embryogenesis.
Title: Spatiotemporal expression of zebrafish keratin 18 during early embryogenesis and the establishment of a keratin 18:RFP transgenic line.

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General gene information

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Markers

krt18 (e-PCR), detects polymorphism
- UniSTS:205583

fk33a09.x1 (e-PCR)
- UniSTS:200833

fb36b04 (e-PCR)
- UniSTS:187102

fb36b04.x1 (e-PCR)
- UniSTS:190458

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 18

Names: CK-18; K18; cytokeratin-18; dorsal aorta proneprin kinesin-1; keratin 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.