selenop selenoprotein P [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: selenopprovided by ZNC
Official Full Name: selenoprotein Pprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030311-1
See related: Ensembl:ENSDARG00000093549 AllianceGenome:ZFIN:ZDB-GENE-030311-1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SePPa; SelPa; cb688; sepp1a; wu:fa55a04; wu:fb38a09; wu:fj79f04
Summary: This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (17 in zebrafish), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. A paralog of this gene exists on chromosome 2 (GeneID:791479). [provided by RefSeq, Aug 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (31435586..31443262)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (31426351..31434014)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data identify core coding region sequence determinants within the SELENOP mRNA that govern SELENOP synthesis. The N-terminal coding sequence (upstream of the second UGA) and C-terminal coding sequence context are two independent determinants for efficient synthesis of full-length SELENOP. In addition, the distance between the first UGA and the consensus signal peptide is also critical for efficiency.
Title: The Selenium Transport Protein, Selenoprotein P, Requires Coding Sequence Determinants to Promote Efficient Selenocysteine Incorporation.

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General gene information

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Markers

fa55a04.s1 (e-PCR)
- UniSTS:202517

fc13c05.x1 (e-PCR)
- UniSTS:203799

aa658625 (e-PCR)
- UniSTS:186916

fj81b01.x1 (e-PCR)
- UniSTS:199982

STS50.G4a (e-PCR)
- UniSTS:205690

AI444404 (e-PCR)
- UniSTS:206564

fj79f04.x1 (e-PCR)
- UniSTS:199933

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables selenium binding	IBA Inferred from Biological aspect of Ancestor more info
enables selenium binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in selenium compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within selenium compound metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: selenoprotein Pa

Names: selenoprotein P, 1a; selenoprotein P, plasma, 1a; zSelPa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178297.4 → NP_840082.3 selenoprotein Pa precursor

Status: REVIEWED

Source sequence(s)

AL929453, AL935153

UniProtKB/Swiss-Prot

Q98SV1

UniProtKB/TrEMBL

A0A8M1PAF5

Related

ENSDARP00000116562.1, ENSDART00000145282.2

Conserved Domains (2) summary

pfam04593
Location:272 → 351

SelP_C; Selenoprotein P, C terminal region

pfam04592
Location:23 → 201

SelP_N; Selenoprotein P, N terminal region