mc2r melanocortin 2 receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mc2rprovided by ZNC
Official Full Name: melanocortin 2 receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030502-2
See related: Ensembl:ENSDARG00000054949 AllianceGenome:ZFIN:ZDB-GENE-030502-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables corticotropin receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; adrenal gland development; and multicellular organismal response to stress. Located in cytoplasm and plasma membrane. Is expressed in adipose tissue; integument; pleuroperitoneal region; and steroid hormone secreting cell. Human ortholog(s) of this gene implicated in West syndrome and glucocorticoid deficiency 1. Orthologous to human MC2R (melanocortin 2 receptor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (30576087..30577001)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (30615870..30619133)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zfMC2R is not functional in the absence of MRAP expression.
Title: Role of melanocortin receptor accessory proteins in the function of zebrafish melanocortin receptor type 2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables corticotropin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables melanocortin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adrenal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adrenocorticotropic hormone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_180971.1 → NP_851302.1 adrenocorticotropic hormone receptor

See identical proteins and their annotated locations for NP_851302.1

Status: PROVISIONAL

Source sequence(s)

AY161848

UniProtKB/TrEMBL

Q7ZTA2

Related

ENSDARP00000071699.2, ENSDART00000077231.3

Conserved Domains (2) summary

pfam00001
Location:35 → 276

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:36 → 172

7tm_4; Olfactory receptor