gnrh2 gonadotropin-releasing hormone 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnrh2provided by ZNC
Official Full Name: gonadotropin-releasing hormone 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030516-1
See related: Ensembl:ENSDARG00000044754 AllianceGenome:ZFIN:ZDB-GENE-030516-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GnRH-II; cGnRH-II
Summary: Predicted to enable gonadotropin hormone-releasing hormone activity and gonadotropin-releasing hormone receptor binding activity. Acts upstream of or within brain development; camera-type eye development; and regulation of feeding behavior. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; female organism; gonad; male organism; and musculature system. Orthologous to human GNRH2 (gonadotropin releasing hormone 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: chromosome: 21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (15824182..15828029)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (15728205..15732052)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GnRH loss-of-function affects early brain and eye formation during development.
Title: A role for GnRH in early brain regionalization and eye development in zebrafish.
cloning of the gene and cDNA encoding cGnRH-II from zebrafish; in situ hybridization analysis of expression in adult zebrafish brains; levels quantified in the pituitary
Title: Molecular characterization of the GnRH system in zebrafish (Danio rerio): cloning of chicken GnRH-II, adult brain expression patterns and pituitary content of salmon GnRH and chicken GnRH-II.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables gonadotropin hormone-releasing hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables gonadotropin-releasing hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: progonadoliberin-2

Names: cII gonadotropin releasing hormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.