tnnc1a troponin C type 1a (slow) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnnc1aprovided by ZNC
Official Full Name: troponin C type 1a (slow)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030523-1
See related: Ensembl:ENSDARG00000011400 AllianceGenome:ZFIN:ZDB-GENE-030523-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cTnC; ctnnc; tnnc1; zgc:103465
Summary: Predicted to enable calcium ion binding activity; calcium-dependent protein binding activity; and troponin I binding activity. Acts upstream of or within cardiac muscle contraction; cardiac ventricle development; and response to activity. Predicted to be part of cardiac Troponin complex. Is expressed in heart primordium; mesoderm; muscle; and pericardial region. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (4890716..4895876)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (4955131..4960291)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that tnnc1a is required both for the function and structural integrity of the contractile machinery in cardiomyocytes, helping to clarify potential mechanisms of troponin C-mediated cardiomyopathy.
Title: Distinct troponin C isoform requirements in cardiac and skeletal muscle.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to activity	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cardiac Troponin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: troponin C type 1a (slow)

Names: sil; troponin C type 1 (slow); troponin C, slow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181498.3 → NP_852475.3 troponin C type 1a (slow)

Status: VALIDATED

Source sequence(s)

CR354596

UniProtKB/TrEMBL

A0A8M1P8B6, Q5XJB2, Q800V7

Related

ENSDARP00000025541.4, ENSDART00000023537.5

Conserved Domains (1) summary

cl25352
Location:9 → 157

EFh_PEF; The penta-EF hand (PEF) family