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RGSL1 regulator of G protein signaling like 1 [ Homo sapiens (human) ]

Gene ID: 353299, updated on 2-Nov-2024

Summary

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Official Symbol
RGSL1provided by HGNC
Official Full Name
regulator of G protein signaling like 1provided by HGNC
Primary source
HGNC:HGNC:18636
See related
Ensembl:ENSG00000121446 MIM:611012; AllianceGenome:HGNC:18636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGSL; RGSL2
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 3.0) See more
Orthologs
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Genomic context

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See RGSL1 in Genome Data Viewer
Location:
1q25.3
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (182447877..182560597)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (181807450..181920071)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182419281..182529732)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1619 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:182408935-182409515 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:182419119-182419726 Neighboring gene transmembrane epididymal protein 2, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:182443692-182444891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2198 Neighboring gene ribonuclease L Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2201 Neighboring gene regulator of G protein signaling 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chick RGS2L demonstrates concentration-dependent selectivity for pertussis toxin-sensitive and -insensitive pathways that inhibit L-type Ca2+ channels. Tosetti P, et al. J Physiol, 2003 May 15. PMID 12651916, Free PMC Article
  2. A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas. Wiechec E, et al. Genes Chromosomes Cancer, 2008 Sep. PMID 18521847
  3. Chromosome 1q25.3 copy number alterations in primary breast cancers detected by multiplex ligation-dependent probe amplification and allelic imbalance assays and its comparison with fluorescent in situ hybridization assays. Wiechec E, et al. Cell Oncol (Dordr), 2013 Apr. PMID 23248035
  4. High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer. Wiechec E, et al. Cancer Epidemiol Biomarkers Prev, 2011 Feb. PMID 21135262
  5. Identification of 9 novel transcripts and two RGSL genes within the hereditary prostate cancer region (HPC1) at 1q25. Silva AP, et al. Gene, 2003 May 22. PMID 12801632

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.
    Title: Chromosome 1q25.3 copy number alterations in primary breast cancers detected by multiplex ligation-dependent probe amplification and allelic imbalance assays and its comparison with fluorescent in situ hybridization assays.
  2. Missense mutations in RGSL1 gene is associated with breast cancer.
    Title: High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
  4. A detailed mapping of the breakpoints revealed intragenic microdeletions affecting the coding regions of RGSL2, RGSL1.
    Title: A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434E169

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling protein-like
Names
regulator of G-protein signaling like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137669.2 → NP_001131141.1  regulator of G-protein signaling protein-like isoform 1

    See identical proteins and their annotated locations for NP_001131141.1

    Status: VALIDATED

    Source sequence(s)
    AF508902, BC142944
    Consensus CDS
    CCDS58049.1
    UniProtKB/Swiss-Prot
    A2A2Z0, A5PLK6, A6PVM2, A6PVM3, Q0VAJ4, Q0VAJ5, Q6ZRL0, Q86UV0, Q9H084
    UniProtKB/TrEMBL
    B7Z814
    Related
    ENSP00000457748.1, ENST00000294854.13
    Conserved Domains (2) summary
    cd08728
    Location:650 → 829
    RGS-like_2; Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2
    cl02565
    Location:876 → 980
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_001366934.1 → NP_001353863.1  regulator of G-protein signaling protein-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL138776, AL139344
    UniProtKB/TrEMBL
    B7Z814

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    182447877..182560597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001193.3 → XP_016856682.1  regulator of G-protein signaling protein-like isoform X2

    UniProtKB/TrEMBL
    B7Z814

  2. XM_017001191.1 → XP_016856680.1  regulator of G-protein signaling protein-like isoform X2

    UniProtKB/TrEMBL
    B7Z814

  3. XM_017001192.3 → XP_016856681.1  regulator of G-protein signaling protein-like isoform X2

    UniProtKB/TrEMBL
    B7Z814

  4. XM_017001189.2 → XP_016856678.1  regulator of G-protein signaling protein-like isoform X2

    UniProtKB/TrEMBL
    B7Z814

  5. XM_017001188.2 → XP_016856677.1  regulator of G-protein signaling protein-like isoform X1

    UniProtKB/TrEMBL
    B7Z814
    Conserved Domains (2) summary
    cd08728
    Location:685 → 864
    RGS-like_2; Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2
    cl02565
    Location:911 → 1015
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  6. XM_047419638.1 → XP_047275594.1  regulator of G-protein signaling protein-like isoform X5

    UniProtKB/TrEMBL
    H3BU64
    Related
    ENSP00000457491.1, ENST00000443996.6

  7. XM_011509494.3 → XP_011507796.1  regulator of G-protein signaling protein-like isoform X3

    See identical proteins and their annotated locations for XP_011507796.1

    UniProtKB/TrEMBL
    B7Z814
    Conserved Domains (2) summary
    cd08728
    Location:685 → 864
    RGS-like_2; Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2
    cl02565
    Location:911 → 1011
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  8. XM_011509500.2 → XP_011507802.1  regulator of G-protein signaling protein-like isoform X6

    Conserved Domains (1) summary
    cl02565
    Location:685 → 782
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  9. XM_017001190.2 → XP_016856679.1  regulator of G-protein signaling protein-like isoform X2

    UniProtKB/TrEMBL
    B7Z814

  10. XM_047419632.1 → XP_047275588.1  regulator of G-protein signaling protein-like isoform X4

  11. XM_017001196.1 → XP_016856685.1  regulator of G-protein signaling protein-like isoform X7

    UniProtKB/Swiss-Prot
    A5PLK6
    Conserved Domains (2) summary
    cd08728
    Location:173 → 352
    RGS-like_2; Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2
    cl02565
    Location:399 → 503
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  12. XM_047419640.1 → XP_047275596.1  regulator of G-protein signaling protein-like isoform X7

  13. XM_047419642.1 → XP_047275598.1  regulator of G-protein signaling protein-like isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    181807450..181920071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336378.1 → XP_054192353.1  regulator of G-protein signaling protein-like isoform X2

  2. XM_054336376.1 → XP_054192351.1  regulator of G-protein signaling protein-like isoform X2

  3. XM_054336377.1 → XP_054192352.1  regulator of G-protein signaling protein-like isoform X2

  4. XM_054336374.1 → XP_054192349.1  regulator of G-protein signaling protein-like isoform X2

  5. XM_054336373.1 → XP_054192348.1  regulator of G-protein signaling protein-like isoform X1

  6. XM_054336381.1 → XP_054192356.1  regulator of G-protein signaling protein-like isoform X5

    UniProtKB/TrEMBL
    H3BU64

  7. XM_054336379.1 → XP_054192354.1  regulator of G-protein signaling protein-like isoform X3

  8. XM_054336382.1 → XP_054192357.1  regulator of G-protein signaling protein-like isoform X6

  9. XM_054336375.1 → XP_054192350.1  regulator of G-protein signaling protein-like isoform X2

  10. XM_054336380.1 → XP_054192355.1  regulator of G-protein signaling protein-like isoform X4

  11. XM_054336384.1 → XP_054192359.1  regulator of G-protein signaling protein-like isoform X7

  12. XM_054336383.1 → XP_054192358.1  regulator of G-protein signaling protein-like isoform X7

  13. XM_054336385.1 → XP_054192360.1  regulator of G-protein signaling protein-like isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032267.2: Suppressed sequence

    Description
    NM_032267.2: This RefSeq was permanently suppressed because it contains a partial CDS and the complete transcript would be a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_181572.2: Suppressed sequence

    Description
    NM_181572.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5PLK6.1 GenPept UniProtKB/Swiss-Prot:A5PLK6

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