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serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [ Danio rerio (zebrafish) ]

Gene ID: 359841, updated on 2-Nov-2024

Summary

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Official Symbol
serpind1provided by ZNC
Official Full Name
serpin peptidase inhibitor, clade D (heparin cofactor), member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030711-2
See related
Ensembl:ENSDARG00000021208 AllianceGenome:ZFIN:ZDB-GENE-030711-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
HCII
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within blood coagulation. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See serpind1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (1766217..1781733)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (1760965..1776527)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene rasGAP-activating-like protein 1 Neighboring gene phosphatidylinositol 4-kinase, catalytic, alpha b Neighboring gene uncharacterized LOC137496286 Neighboring gene synaptosome associated protein 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor. Wu TS, et al. Chemosphere, 2020 Mar. PMID 31675585
  2. Cloning of six serpin genes and their responses to GCRV infection in grass carp (Ctenopharyngodon idella). Chen L, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30439497
  3. Inhibition of SERPINe1 reduces rhabdoviral infections in zebrafish. Estepa A, et al. Fish Shellfish Immunol, 2015 Nov. PMID 26363229, Free PMC Article
  4. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Li Q, et al. Dis Model Mech, 2011 Nov. PMID 21816950, Free PMC Article
  5. Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. Lopez-Rivera E, et al. N Engl J Med, 2017 Feb 23. PMID 28121514, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heparin cofactor 2
Names
serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182880.1 → NP_878300.1  heparin cofactor 2 precursor

    See identical proteins and their annotated locations for NP_878300.1

    Status: PROVISIONAL

    Source sequence(s)
    AF515273
    UniProtKB/TrEMBL
    Q8AYE2
    Related
    ENSDARP00000073528.4, ENSDART00000079073.7
    Conserved Domains (1) summary
    cd02047
    Location:61 → 505
    HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    1766217..1781733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166737.5 → XP_005166794.1  heparin cofactor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BE52, B0V3R7
    Related
    ENSDARP00000017995.7, ENSDART00000021820.9
    Conserved Domains (1) summary
    cd02047
    Location:61 → 505
    HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

  2. XM_068222887.1 → XP_068078988.1  heparin cofactor 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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