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Mrm3 mitochondrial rRNA methyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360569, updated on 2-Nov-2024

Summary

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Official Symbol
Mrm3provided by RGD
Official Full Name
mitochondrial rRNA methyltransferase 3provided by RGD
Primary source
RGD:1309077
See related
EnsemblRapid:ENSRNOG00000037238 AllianceGenome:RGD:1309077
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rnmtl1; RGD1309077
Summary
Predicted to enable identical protein binding activity and rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA 2'-O-methylation. Predicted to be located in mitochondrion. Orthologous to human MRM3 (mitochondrial rRNA methyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 67.4), Muscle (RPKM 63.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrm3 in Genome Data Viewer
Location:
10q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (61594155..61623659)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (61095920..61125421)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (64398308..64406193)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene diazepam binding inhibitor-like 5 Neighboring gene glyoxalase domain containing 4 Neighboring gene nucleoredoxin Neighboring gene uncharacterized LOC120095143 Neighboring gene translocase of inner mitochondrial membrane 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA). Lee KW, et al. J Biol Chem, 2014 Sep 5. PMID 25074936, Free PMC Article
  2. Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid. Lee KW, et al. J Biol Chem, 2013 Oct 25. PMID 24036117, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables rRNA (guanosine-2'-O-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in rRNA 2'-O-methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rRNA methyltransferase 3, mitochondrial
Names
RNA methyltransferase like 1
RNA methyltransferase-like protein 1
NP_001101752.1
XP_017452868.1
XP_038942255.1
XP_038942256.1
XP_038942257.1
XP_038942258.1
XP_038942259.1
XP_038942260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108282.1 → NP_001101752.1  rRNA methyltransferase 3, mitochondrial

    See identical proteins and their annotated locations for NP_001101752.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HGV3, D3ZQG0
    Related
    ENSRNOP00000053117.4, ENSRNOT00000056278.5
    Conserved Domains (2) summary
    smart00967
    Location:125 → 191
    SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding
    cd18106
    Location:210 → 400
    SpoU-like_RNMTL1; SAM-dependent rRNA methylase related to RNMTL1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    61594155..61623659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086330.2 → XP_038942258.1  rRNA methyltransferase 3, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl38912
    Location:117 → 254
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

  2. XM_039086327.2 → XP_038942255.1  rRNA methyltransferase 3, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl38912
    Location:117 → 254
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

  3. XM_039086328.2 → XP_038942256.1  rRNA methyltransferase 3, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl38912
    Location:117 → 243
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

  4. XM_039086329.2 → XP_038942257.1  rRNA methyltransferase 3, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl38912
    Location:117 → 243
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

  5. XM_039086332.2 → XP_038942260.1  rRNA methyltransferase 3, mitochondrial isoform X6

    Conserved Domains (1) summary
    cl38912
    Location:117 → 243
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

  6. XM_039086331.2 → XP_038942259.1  rRNA methyltransferase 3, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl38912
    Location:117 → 243
    SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

  7. XM_017597379.3 → XP_017452868.1  rRNA methyltransferase 3, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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