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Zfp157 zinc finger protein 157 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360775, updated on 28-Oct-2024

Summary

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Official Symbol
Zfp157provided by RGD
Official Full Name
zinc finger protein 157provided by RGD
Primary source
RGD:1359435
See related
EnsemblRapid:ENSRNOG00000001323 AllianceGenome:RGD:1359435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AZ61; RGD1359435
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within lung alveolus development; mammary gland morphogenesis; and regulation of cell fate commitment. Predicted to be active in nucleus. Orthologous to human ZNF157 (zinc finger protein 157). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 124.5), Thymus (RPKM 68.2) and 9 other tissues See more
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Genomic context

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See Zfp157 in Genome Data Viewer
Location:
12q11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21356253..21393006, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16248230..16279459, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (18461283..18495871, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene sialophorin, pseudogene 5 Neighboring gene sialophorin, pseudogene 3 Neighboring gene uncharacterized LOC134481271 Neighboring gene olfactory receptor family 7 subfamily A member 43, pseudogene 1 Neighboring gene dehydrogenase/reductase X-linked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of zinc finger encoding genes from the tumoral exocrine pancreatic cell line AR42J. Mesa K, et al. Cancer Lett, 1996 Jun 5. PMID 8635150
  2. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Oliver CH, et al. Genes Dev, 2012 May 15. PMID 22588720, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mammary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell fate commitment ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 157
Names
zinc finger protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170404.1 → NP_001163875.1  zinc finger protein 157

    Status: VALIDATED

    Source sequence(s)
    FM039106, JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZFZ1
    Related
    ENSRNOP00000036664.4, ENSRNOT00000030757.7
    Conserved Domains (6) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:182 → 528
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:436 → 458
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:339 → 363
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    21356253..21393006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271474.1 → XP_063127544.1  zinc finger protein 157 isoform X4

  2. XM_039089570.2 → XP_038945498.1  zinc finger protein 157 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:234 → 390
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. XM_017598383.3 → XP_017453872.1  zinc finger protein 157 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:234 → 390
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. XM_039089573.2 → XP_038945501.1  zinc finger protein 157 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:234 → 390
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  5. XM_039089571.2 → XP_038945499.1  zinc finger protein 157 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:234 → 390
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350 → 370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  6. XM_039089575.2 → XP_038945503.1  zinc finger protein 157 isoform X5

    Conserved Domains (1) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box

  7. XM_063271473.1 → XP_063127543.1  zinc finger protein 157 isoform X2

    Related
    ENSRNOP00000093142.2, ENSRNOT00000117344.2

  8. XM_039089568.2 → XP_038945496.1  zinc finger protein 157 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIG3
    Conserved Domains (3) summary
    smart00349
    Location:5 → 65
    KRAB; krueppel associated box
    COG5048
    Location:183 → 529
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:383 → 403
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_039089574.2 → XP_038945502.1  zinc finger protein 157 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:152 → 308
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_010056404.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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