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Cars2 cysteinyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 361184, updated on 2-Nov-2024

Summary

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Official Symbol
Cars2provided by RGD
Official Full Name
cysteinyl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source
RGD:1311612
See related
EnsemblRapid:ENSRNOG00000014526 AllianceGenome:RGD:1311612
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311612
Summary
Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 93.0), Liver (RPKM 79.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cars2 in Genome Data Viewer
Location:
16q12.5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (84649617..84689254)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (77945468..77987163)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (83288613..83325706)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097568 Neighboring gene ankyrin repeat domain 10 Neighboring gene inhibitor of growth family, member 1 Neighboring gene uncharacterized LOC134482536 Neighboring gene NAD(P)HX dehydratase Neighboring gene uncharacterized LOC102553902 Neighboring gene RAB20, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cysteinyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteinyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable cysteine--tRNA ligase, mitochondrial
NP_001171155.1
XP_006253522.3
XP_006253523.3
XP_006253524.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177684.1 → NP_001171155.1  probable cysteine--tRNA ligase, mitochondrial

    See identical proteins and their annotated locations for NP_001171155.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166536
    UniProtKB/TrEMBL
    A6IWP2, B2GV57, D4A5T2
    Related
    ENSRNOP00000019993.7, ENSRNOT00000019993.8
    Conserved Domains (3) summary
    cd00672
    Location:38 → 342
    CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
    COG0215
    Location:38 → 539
    CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cl12020
    Location:391 → 427
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    84649617..84689254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253460.5 → XP_006253522.3  probable cysteine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXZ9
    Conserved Domains (1) summary
    PTZ00399
    Location:157 → 664
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  2. XM_006253461.5 → XP_006253523.3  probable cysteine--tRNA ligase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZXZ9
    Related
    ENSRNOP00000084040.2, ENSRNOT00000096918.2
    Conserved Domains (1) summary
    PTZ00399
    Location:157 → 663
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  3. XM_006253462.5 → XP_006253524.3  probable cysteine--tRNA ligase, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6IWP2
    Conserved Domains (1) summary
    PTZ00399
    Location:157 → 680
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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