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Ccar1 cell division cycle and apoptosis regulator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361849, updated on 2-Nov-2024

Summary

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Symbol
Ccar1provided by RGD
Full Name
cell division cycle and apoptosis regulator 1provided by RGD
Primary source
RGD:1560358
See related
EnsemblRapid:ENSRNOG00000000397 AllianceGenome:RGD:1560358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560358
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Predicted to be involved in positive regulation of cell migration; positive regulation of cell population proliferation; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in nuclear envelope lumen. Predicted to be active in nucleus. Orthologous to human CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 104.6), Spleen (RPKM 90.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccar1 in Genome Data Viewer
Location:
20q11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31228624..31271233, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30685916..30728531, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32373443..32416044, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene storkhead box 1 Neighboring gene uncharacterized LOC108349068 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene uncharacterized LOC120098953 Neighboring gene vacuolar protein sorting 36, pseudogene 1 Neighboring gene radial spoke head component 4A Neighboring gene lysyl-tRNA synthetase 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2. Seo WY, et al. Nucleic Acids Res, 2013 Oct. PMID 23887938, Free PMC Article
  2. Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437. Rishi AK, et al. J Biol Chem, 2003 Aug 29. PMID 12816952
  3. CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Kim JH, et al. Mol Cell, 2008 Aug 22. PMID 18722177, Free PMC Article
  4. CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. Mizuta S, et al. Genes Cells, 2014 Jan. PMID 24245781, Free PMC Article
  5. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell division cycle and apoptosis regulator protein 1
Names
cell division cycle and apoptosis regulator protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108535.1 → NP_001102005.1  cell division cycle and apoptosis regulator protein 1

    See identical proteins and their annotated locations for NP_001102005.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474016
    UniProtKB/TrEMBL
    A0A8I6A183, A6K465
    Related
    ENSRNOP00000085003.1, ENSRNOT00000097504.2
    Conserved Domains (6) summary
    smart00513
    Location:634 → 667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PHA03356
    Location:278 → 310
    PHA03356; tegument protein UL11; Provisional
    pfam13499
    Location:922 → 988
    EF-hand_7; EF-hand domain pair
    pfam14443
    Location:479 → 598
    DBC1; DBC1
    pfam14444
    Location:149 → 201
    S1-like; S1-like
    cl01797
    Location:935 → 1099
    DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    31228624..31271233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279307.1 → XP_063135377.1  cell division cycle and apoptosis regulator protein 1 isoform X3

  2. XM_063279308.1 → XP_063135378.1  cell division cycle and apoptosis regulator protein 1 isoform X4

  3. XM_063279306.1 → XP_063135376.1  cell division cycle and apoptosis regulator protein 1 isoform X2

    UniProtKB/TrEMBL
    A6K465

  4. XM_006256463.4 → XP_006256525.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006256525.1

    UniProtKB/TrEMBL
    A0A8I6A183, D4A2P1
    Conserved Domains (6) summary
    smart00513
    Location:634 → 667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PHA03356
    Location:278 → 310
    PHA03356; tegument protein UL11; Provisional
    pfam13499
    Location:931 → 997
    EF-hand_7; EF-hand domain pair
    pfam14443
    Location:479 → 598
    DBC1; DBC1
    pfam14444
    Location:149 → 201
    S1-like; S1-like
    cl01797
    Location:944 → 1108
    DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

  5. XM_063279311.1 → XP_063135381.1  cell division cycle and apoptosis regulator protein 1 isoform X6

  6. XM_039098883.2 → XP_038954811.1  cell division cycle and apoptosis regulator protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A183
    Conserved Domains (5) summary
    smart00513
    Location:619 → 652
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PRK10927
    Location:169 → 288
    PRK10927; cell division protein FtsN
    pfam14443
    Location:461 → 586
    DBC1
    pfam14444
    Location:130 → 186
    S1-like
    pfam15905
    Location:1033 → 1138
    HMMR_N; Hyaluronan mediated motility receptor N-terminal

  7. XM_006256464.5 → XP_006256526.1  cell division cycle and apoptosis regulator protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A183
    Conserved Domains (5) summary
    PHA03356
    Location:278 → 310
    PHA03356; tegument protein UL11; Provisional
    pfam13499
    Location:869 → 935
    EF-hand_7; EF-hand domain pair
    pfam14443
    Location:479 → 598
    DBC1; DBC1
    pfam14444
    Location:149 → 201
    S1-like; S1-like
    cl01797
    Location:882 → 1046
    DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

  8. XM_006256462.4 → XP_006256524.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006256524.1

    UniProtKB/TrEMBL
    A0A8I6A183, D4A2P1
    Related
    ENSRNOP00000059432.3, ENSRNOT00000067004.4
    Conserved Domains (6) summary
    smart00513
    Location:634 → 667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PHA03356
    Location:278 → 310
    PHA03356; tegument protein UL11; Provisional
    pfam13499
    Location:931 → 997
    EF-hand_7; EF-hand domain pair
    pfam14443
    Location:479 → 598
    DBC1; DBC1
    pfam14444
    Location:149 → 201
    S1-like; S1-like
    cl01797
    Location:944 → 1108
    DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

  9. XM_063279309.1 → XP_063135379.1  cell division cycle and apoptosis regulator protein 1 isoform X4

  10. XM_008772894.3 → XP_008771116.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008771116.1

    UniProtKB/TrEMBL
    A0A8I6A183, D4A2P1
    Conserved Domains (6) summary
    smart00513
    Location:634 → 667
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PHA03356
    Location:278 → 310
    PHA03356; tegument protein UL11; Provisional
    pfam13499
    Location:931 → 997
    EF-hand_7; EF-hand domain pair
    pfam14443
    Location:479 → 598
    DBC1; DBC1
    pfam14444
    Location:149 → 201
    S1-like; S1-like
    cl01797
    Location:944 → 1108
    DUF2258; Uncharacterized protein conserved in archaea (DUF2258)

  11. XM_063279305.1 → XP_063135375.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    UniProtKB/TrEMBL
    D4A2P1

  12. XM_063279304.1 → XP_063135374.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    UniProtKB/TrEMBL
    D4A2P1

  13. XM_063279310.1 → XP_063135380.1  cell division cycle and apoptosis regulator protein 1 isoform X5

  14. XM_063279303.1 → XP_063135373.1  cell division cycle and apoptosis regulator protein 1 isoform X1

    UniProtKB/TrEMBL
    D4A2P1

  15. XM_008772897.4 → XP_008771119.1  cell division cycle and apoptosis regulator protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A183
    Conserved Domains (4) summary
    smart00513
    Location:442 → 475
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    PHA03356
    Location:86 → 118
    PHA03356; tegument protein UL11; Provisional
    pfam13499
    Location:739 → 805
    EF-hand_7; EF-hand domain pair
    pfam14443
    Location:287 → 406
    DBC1; DBC1
Nucleotide Protein Strain
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