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Stxbp6 syntaxin binding protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362734, updated on 2-Nov-2024

Summary

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Official Symbol
Stxbp6provided by RGD
Official Full Name
syntaxin binding protein 6provided by RGD
Primary source
RGD:1306117
See related
EnsemblRapid:ENSRNOG00000004198 AllianceGenome:RGD:1306117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Amisyn
Summary
Predicted to be involved in regulation of SNARE complex assembly. Orthologous to human STXBP6 (syntaxin binding protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 87.5), Brain (RPKM 74.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stxbp6 in Genome Data Viewer
Location:
6q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (67647721..67884369, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (61920756..62157405, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (65086483..65319527, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene enolase 1, pseudogene 32 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 92 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PI(4,5)P(2)-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2. Kondratiuk I, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32467162, Free PMC Article
  2. Amisyn regulates exocytosis and fusion pore stability by both syntaxin-dependent and syntaxin-independent mechanisms. Constable JR, et al. J Biol Chem, 2005 Sep 9. PMID 16033762
  3. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. Scales SJ, et al. J Biol Chem, 2002 Aug 2. PMID 12145319
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PI(4,5)P2-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2.
    Title: PI(4,5)P(2)-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2.
  2. Amisyn is a novel syntaxin-binding protein that may regulate SNARE complex assembly.
    Title: Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly.
  3. Can negatively regulate exocytosis independently of syntaxin and can also regulate the stability of the fusion pore.
    Title: Amisyn regulates exocytosis and fusion pore stability by both syntaxin-dependent and syntaxin-independent mechanisms.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of SNARE complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of SNARE complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of SNARE complex assembly IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
syntaxin-binding protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191872.1 → NP_001178801.1  syntaxin-binding protein 6

    See identical proteins and their annotated locations for NP_001178801.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5ZQ52, A0A8I6A7D8
    Related
    ENSRNOP00000005618.6, ENSRNOT00000005618.7
    Conserved Domains (2) summary
    cd14681
    Location:2 → 131
    PH-STXBP6; PH-like domain of Syntaxin binding protein 6
    cd15892
    Location:149 → 210
    R-SNARE_STXBP6; SNARE domain of STXBP6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    67647721..67884369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262101.1 → XP_063118171.1  syntaxin-binding protein 6 isoform X2

  2. XM_008764658.4 → XP_008762880.1  syntaxin-binding protein 6 isoform X1

    See identical proteins and their annotated locations for XP_008762880.1

    UniProtKB/TrEMBL
    A0A8I5ZQ52, A0A8I6A7D8
    Conserved Domains (2) summary
    cd14681
    Location:2 → 131
    PH-STXBP6; PH-like domain of Syntaxin binding protein 6
    cd15892
    Location:149 → 210
    R-SNARE_STXBP6; SNARE domain of STXBP6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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