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Glce glucuronic acid epimerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 363073, updated on 2-Nov-2024

Summary

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Official Symbol
Glceprovided by RGD
Official Full Name
glucuronic acid epimeraseprovided by RGD
Primary source
RGD:1565253
See related
EnsemblRapid:ENSRNOG00000025372 AllianceGenome:RGD:1565253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565253
Summary
Predicted to enable calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in negative regulation of cell projection organization; positive regulation of SMAD protein signal transduction; and positive regulation of cell population proliferation. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in cerebrovascular disease and hypertension. Orthologous to human GLCE (glucuronic acid epimerase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 156.8), Thymus (RPKM 146.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Glce in Genome Data Viewer
Location:
8q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (71441607..71507639, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (62546104..62612144, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (67006588..67073723, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 23 Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene mitochondrial ribosomal protein S16, pseudogene 1 Neighboring gene sperm equatorial segment protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. Debarnot C, et al. Proc Natl Acad Sci U S A, 2019 Apr 2. PMID 30872481, Free PMC Article
  2. Glucuronic Acid Epimerase (GLCE) Variant rs3865014 (A>G) Is Associated with BMI, Blood Hemoglobin, Hypertension, and Cerebrovascular Events, the TAMRISK Study. Kunnas T, et al. Ann Hum Genet, 2016 Nov. PMID 27699767
  3. GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling. Li J, et al. Biochem J, 2014 Apr 15. PMID 24499487
  4. Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality. Li JP, et al. J Biol Chem, 2003 Aug 1. PMID 12788935
  5. Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutants. Li K, et al. J Biol Chem, 2010 Apr 9. PMID 20118238, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The function of GLCE in neuritogenesis via SMAD/ID3 signalling was studied via mutagenesis and gene silencing studies.
    Title: GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables heparosan-N-sulfate-glucuronate 5-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparosan-N-sulfate-glucuronate 5-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables racemase and epimerase activity, acting on carbohydrates and derivatives ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heparin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell projection organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
D-glucuronyl C5-epimerase
Names
glucuronyl C5-epimerase
NP_001414556.1
XP_038938365.1
XP_063121830.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427627.1 → NP_001414556.1  D-glucuronyl C5-epimerase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J572, D3ZIK0
    Related
    ENSRNOP00000037789.4, ENSRNOT00000038641.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    71441607..71507639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265760.1 → XP_063121830.1  D-glucuronyl C5-epimerase isoform X1

    UniProtKB/TrEMBL
    A6J572, D3ZIK0

  2. XM_039082437.2 → XP_038938365.1  D-glucuronyl C5-epimerase isoform X1

    UniProtKB/TrEMBL
    A6J572, D3ZIK0
    Conserved Domains (1) summary
    pfam06662
    Location:417 → 608
    C5-epim_C; D-glucuronyl C5-epimerase C-terminus
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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