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Bend6 BEN domain containing 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363212, updated on 6-Jun-2024

Summary

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Official Symbol
Bend6provided by RGD
Official Full Name
BEN domain containing 6provided by RGD
Primary source
RGD:1310392
See related
Ensembl:ENSRNOG00000052376 AllianceGenome:RGD:1310392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310392
Summary
Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Predicted to be active in nucleus. Orthologous to human BEND6 (BEN domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 487.6) and Lung (RPKM 27.2) See more
Orthologs
human mouse all
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Genomic context

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See Bend6 in Genome Data Viewer
Location:
9q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (43576982..43631437, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36081033..36135309, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (38297253..38351312)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 5 Neighboring gene zinc finger protein 451 Neighboring gene ribosomal protein S18, pseudogene 7 Neighboring gene dystonin Neighboring gene uncharacterized LOC102551615 Neighboring gene uncharacterized LOC134480566

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Dai Q, et al. Genes Dev, 2015 Jan 1. PMID 25561495, Free PMC Article
  2. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Dai Q, et al. Development, 2013 May. PMID 23571214, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BEN domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393774.1 → NP_001380703.1  BEN domain-containing protein 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K8T8, A6IN97
    Related
    ENSRNOP00000074733.2, ENSRNOT00000078157.2
    Conserved Domains (2) summary
    smart01025
    Location:190 → 267
    BEN; The BEN domain is found in diverse animal proteins
    NF033175
    Location:46 → 95
    fuso_auto_Nterm; autotransporter-associated N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    43576982..43631437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267364.1 → XP_063123434.1  BEN domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K8T8, A6IN97

RNA

  1. XR_010054613.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108792.2: Suppressed sequence

    Description
    NM_001108792.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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