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Lrrfip1 LRR binding FLII interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367314, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrfip1provided by RGD
Official Full Name
LRR binding FLII interacting protein 1provided by RGD
Primary source
RGD:1359548
See related
EnsemblRapid:ENSRNOG00000019892 AllianceGenome:RGD:1359548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human LRRFIP1 (LRR binding FLII interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 206.1), Heart (RPKM 149.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrfip1 in Genome Data Viewer
Location:
9q36
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99039590..99167805)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (91592032..91720250)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98139484..98268148)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene prolactin releasing hormone Neighboring gene RAB17, member RAS oncogene family Neighboring gene RNA binding motif protein 44 Neighboring gene receptor activity modifying protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The alternatively spliced LRRFIP1 Isoform-1 is a key regulator of the Wnt/β-catenin transcription pathway. Labbé P, et al. Biochim Biophys Acta Mol Cell Res, 2017 Jul. PMID 28322931
  2. Characterization of Gcf2/Lrrfip1 in experimental cerebral ischemia and its role as a modulator of Akt, mTOR and β-catenin signaling pathways. Gubern C, et al. Neuroscience, 2014 May 30. PMID 24637094
  3. The microRNA miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia. Choe N, et al. Atherosclerosis, 2013 Aug. PMID 23880186
  4. Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1. Nguyen JB, et al. J Struct Biol, 2013 Jan. PMID 23099021, Free PMC Article
  5. GCF2: expression and molecular analysis of repression. Rikiyama T, et al. Biochim Biophys Acta, 2003 Oct 1. PMID 14522076

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRRFIP1-Iso1 is a muscle and cardiomyocyte specific Wnt transcription co-factor.
    Title: The alternatively spliced LRRFIP1 Isoform-1 is a key regulator of the Wnt/β-catenin transcription pathway.
  2. Results identify LRRFIP1, SMARCA4, and DNMT1 as novel regulators of macrophage multinucleation.
    Title: Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.
  3. First report to identify the different transcriptional variants of Lrrfip1 in the brain and to characterize their differential expression patterns and the subcellular location of the main isoform rLrrfip1 in ischemic conditions
    Title: Characterization of Gcf2/Lrrfip1 in experimental cerebral ischemia and its role as a modulator of Akt, mTOR and β-catenin signaling pathways.
  4. Our results suggest that miR-132 is a novel regulator of vascular smooth muscle cells proliferation that represses neointimal formation by inhibiting LRRFIP1 expression.
    Title: The microRNA miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat flightless-interacting protein 1
Names
LRR FLII-interacting protein 1
leucine rich repeat (in FLII) interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014269.1 → NP_001014291.1  leucine-rich repeat flightless-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001014291.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081883
    UniProtKB/Swiss-Prot
    Q66HF9
    UniProtKB/TrEMBL
    A0A8L2QNX6, A6JQP6
    Related
    ENSRNOP00000045021.3, ENSRNOT00000050191.4
    Conserved Domains (1) summary
    pfam09738
    Location:42 → 278
    DUF2051; Double stranded RNA binding protein (DUF2051)

  2. NM_001429351.1 → NP_001416280.1  leucine-rich repeat flightless-interacting protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    99039590..99167805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245444.5 → XP_006245506.1  leucine-rich repeat flightless-interacting protein 1 isoform X1

    Related
    ENSRNOP00000112353.1, ENSRNOT00000153243.1
    Conserved Domains (2) summary
    pfam09738
    Location:260 → 572
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl12057
    Location:410 → 487
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  2. XM_006245458.5 → XP_006245520.1  leucine-rich repeat flightless-interacting protein 1 isoform X22

    UniProtKB/TrEMBL
    A0A8L2QNX6
    Conserved Domains (1) summary
    pfam09738
    Location:52 → 288
    DUF2051; Double stranded RNA binding protein (DUF2051)

  3. XM_006245459.4 → XP_006245521.1  leucine-rich repeat flightless-interacting protein 1 isoform X23

    UniProtKB/TrEMBL
    A6JQN7
    Conserved Domains (2) summary
    COG1340
    Location:410 → 680
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cl12057
    Location:410 → 487
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  4. XM_039083994.1 → XP_038939922.1  leucine-rich repeat flightless-interacting protein 1 isoform X28

    UniProtKB/TrEMBL
    A6JQN7
    Conserved Domains (2) summary
    pfam09738
    Location:260 → 582
    LRRFIP; LRRFIP family
    pfam11932
    Location:598 → 657
    DUF3450; Protein of unknown function (DUF3450)

  5. XM_006245462.5 → XP_006245524.1  leucine-rich repeat flightless-interacting protein 1 isoform X31

    UniProtKB/TrEMBL
    A6JQN8
    Conserved Domains (1) summary
    pfam09738
    Location:260 → 550
    DUF2051; Double stranded RNA binding protein (DUF2051)

  6. XM_063267530.1 → XP_063123600.1  leucine-rich repeat flightless-interacting protein 1 isoform X26

  7. XM_039083995.2 → XP_038939923.1  leucine-rich repeat flightless-interacting protein 1 isoform X30

    UniProtKB/TrEMBL
    A6JQN7
    Conserved Domains (2) summary
    pfam09738
    Location:260 → 558
    LRRFIP; LRRFIP family
    pfam11932
    Location:574 → 633
    DUF3450; Protein of unknown function (DUF3450)

  8. XM_006245463.5 → XP_006245525.1  leucine-rich repeat flightless-interacting protein 1 isoform X34

    UniProtKB/TrEMBL
    A6JQN8
    Conserved Domains (1) summary
    pfam09738
    Location:260 → 526
    DUF2051; Double stranded RNA binding protein (DUF2051)

  9. XM_006245460.5 → XP_006245522.1  leucine-rich repeat flightless-interacting protein 1 isoform X25

    UniProtKB/TrEMBL
    A6JQN7
    Conserved Domains (1) summary
    COG1340
    Location:395 → 665
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

  10. XM_063267533.1 → XP_063123603.1  leucine-rich repeat flightless-interacting protein 1 isoform X33

  11. XM_063267531.1 → XP_063123601.1  leucine-rich repeat flightless-interacting protein 1 isoform X29

  12. XM_063267532.1 → XP_063123602.1  leucine-rich repeat flightless-interacting protein 1 isoform X32

  13. XM_063267534.1 → XP_063123604.1  leucine-rich repeat flightless-interacting protein 1 isoform X35

  14. XM_063267535.1 → XP_063123605.1  leucine-rich repeat flightless-interacting protein 1 isoform X36

  15. XM_063267536.1 → XP_063123606.1  leucine-rich repeat flightless-interacting protein 1 isoform X37

  16. XM_063267537.1 → XP_063123607.1  leucine-rich repeat flightless-interacting protein 1 isoform X38

  17. XM_063267538.1 → XP_063123608.1  leucine-rich repeat flightless-interacting protein 1 isoform X39

  18. XM_039083999.2 → XP_038939927.1  leucine-rich repeat flightless-interacting protein 1 isoform X47

    UniProtKB/TrEMBL
    A6JQP5
    Conserved Domains (2) summary
    pfam09738
    Location:52 → 415
    LRRFIP; LRRFIP family
    pfam11932
    Location:431 → 490
    DUF3450; Protein of unknown function (DUF3450)

  19. XM_039084000.2 → XP_038939928.1  leucine-rich repeat flightless-interacting protein 1 isoform X48

    UniProtKB/TrEMBL
    A6JQP5
    Conserved Domains (2) summary
    pfam09738
    Location:52 → 384
    LRRFIP; LRRFIP family
    pfam11932
    Location:400 → 459
    DUF3450; Protein of unknown function (DUF3450)

  20. XM_006245464.5 → XP_006245526.1  leucine-rich repeat flightless-interacting protein 1 isoform X41

    See identical proteins and their annotated locations for XP_006245526.1

    UniProtKB/TrEMBL
    A6JQN9, A6JQP5
    Conserved Domains (1) summary
    pfam09738
    Location:52 → 352
    DUF2051; Double stranded RNA binding protein (DUF2051)

  21. XM_039084002.2 → XP_038939930.1  leucine-rich repeat flightless-interacting protein 1 isoform X49

    UniProtKB/TrEMBL
    A6JQP5
    Conserved Domains (2) summary
    pfam09738
    Location:52 → 391
    LRRFIP; LRRFIP family
    pfam11932
    Location:407 → 466
    DUF3450; Protein of unknown function (DUF3450)

  22. XM_039083996.2 → XP_038939924.1  leucine-rich repeat flightless-interacting protein 1 isoform X40

    Conserved Domains (2) summary
    pfam09738
    Location:52 → 360
    LRRFIP; LRRFIP family
    pfam11932
    Location:376 → 435
    DUF3450; Protein of unknown function (DUF3450)

  23. XM_006245465.5 → XP_006245527.1  leucine-rich repeat flightless-interacting protein 1 isoform X44

    See identical proteins and their annotated locations for XP_006245527.1

    UniProtKB/TrEMBL
    A6JQP0, A6JQP5
    Conserved Domains (1) summary
    pfam09738
    Location:52 → 328
    DUF2051; Double stranded RNA binding protein (DUF2051)

  24. XM_006245448.4 → XP_006245510.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

    Conserved Domains (2) summary
    pfam09738
    Location:260 → 541
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl23720
    Location:388 → 456
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  25. XM_006245450.5 → XP_006245512.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

    Related
    ENSRNOP00000077964.2, ENSRNOT00000100450.2
    Conserved Domains (1) summary
    pfam09738
    Location:260 → 510
    DUF2051; Double stranded RNA binding protein (DUF2051)

  26. XM_006245447.4 → XP_006245509.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

    Conserved Domains (2) summary
    pfam09738
    Location:260 → 548
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl12057
    Location:386 → 463
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  27. XM_039083983.1 → XP_038939911.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

    Conserved Domains (1) summary
    pfam09738
    Location:260 → 537
    LRRFIP; LRRFIP family

  28. XM_006245452.5 → XP_006245514.1  leucine-rich repeat flightless-interacting protein 1 isoform X10

    Conserved Domains (1) summary
    pfam09738
    Location:260 → 486
    DUF2051; Double stranded RNA binding protein (DUF2051)

  29. XM_006245446.4 → XP_006245508.1  leucine-rich repeat flightless-interacting protein 1 isoform X4

    Related
    ENSRNOP00000080509.2, ENSRNOT00000100990.2
    Conserved Domains (2) summary
    pfam09738
    Location:245 → 557
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl12057
    Location:395 → 472
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  30. XM_008767285.3 → XP_008765507.1  leucine-rich repeat flightless-interacting protein 1 isoform X3

    Conserved Domains (2) summary
    pfam09738
    Location:247 → 559
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl12057
    Location:397 → 474
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  31. XM_017596579.3 → XP_017452068.1  leucine-rich repeat flightless-interacting protein 1 isoform X11

  32. XM_063267521.1 → XP_063123591.1  leucine-rich repeat flightless-interacting protein 1 isoform X12

  33. XM_006245455.5 → XP_006245517.1  leucine-rich repeat flightless-interacting protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8L2QNX6
    Conserved Domains (2) summary
    pfam09738
    Location:52 → 374
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl12057
    Location:212 → 289
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  34. XM_063267526.1 → XP_063123596.1  leucine-rich repeat flightless-interacting protein 1 isoform X19

  35. XM_063267522.1 → XP_063123592.1  leucine-rich repeat flightless-interacting protein 1 isoform X15

  36. XM_063267525.1 → XP_063123595.1  leucine-rich repeat flightless-interacting protein 1 isoform X18

  37. XM_063267539.1 → XP_063123609.1  leucine-rich repeat flightless-interacting protein 1 isoform X42

  38. XM_039083997.2 → XP_038939925.1  leucine-rich repeat flightless-interacting protein 1 isoform X45

    UniProtKB/TrEMBL
    A6JQP4
    Conserved Domains (2) summary
    pfam09738
    Location:42 → 319
    LRRFIP; LRRFIP family
    pfam11932
    Location:335 → 394
    DUF3450; Protein of unknown function (DUF3450)

  39. XM_006245457.4 → XP_006245519.1  leucine-rich repeat flightless-interacting protein 1 isoform X16

    UniProtKB/TrEMBL
    A0A8I5Y5U1, A0A8L2QNX6
    Related
    ENSRNOP00000076434.1, ENSRNOT00000100660.2
    Conserved Domains (2) summary
    pfam09738
    Location:42 → 340
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl12057
    Location:178 → 255
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  40. XM_063267527.1 → XP_063123597.1  leucine-rich repeat flightless-interacting protein 1 isoform X20

  41. XM_006245445.5 → XP_006245507.1  leucine-rich repeat flightless-interacting protein 1 isoform X2

    Conserved Domains (2) summary
    pfam09738
    Location:250 → 562
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl12057
    Location:400 → 477
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  42. XM_039083982.2 → XP_038939910.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

    Conserved Domains (2) summary
    TIGR02168
    Location:363 → 463
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09738
    Location:237 → 569
    LRRFIP; LRRFIP family

  43. XM_063267529.1 → XP_063123599.1  leucine-rich repeat flightless-interacting protein 1 isoform X24

    UniProtKB/TrEMBL
    A0A8I6A6Y5
    Related
    ENSRNOP00000088829.1, ENSRNOT00000095067.2

  44. XM_006245461.5 → XP_006245523.1  leucine-rich repeat flightless-interacting protein 1 isoform X27

    UniProtKB/TrEMBL
    A0A8I5Y1S8, A6JQP1
    Conserved Domains (1) summary
    COG1340
    Location:385 → 655
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

  45. XM_039083998.2 → XP_038939926.1  leucine-rich repeat flightless-interacting protein 1 isoform X46

    UniProtKB/TrEMBL
    A6JQP1
    Related
    ENSRNOP00000095213.2, ENSRNOT00000119489.2
    Conserved Domains (2) summary
    pfam09738
    Location:222 → 575
    LRRFIP; LRRFIP family
    pfam11932
    Location:591 → 650
    DUF3450; Protein of unknown function (DUF3450)

  46. XM_006245456.4 → XP_006245518.1  leucine-rich repeat flightless-interacting protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A8L2QNX6
    Conserved Domains (2) summary
    pfam09738
    Location:42 → 364
    DUF2051; Double stranded RNA binding protein (DUF2051)
    cl12057
    Location:202 → 279
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

  47. XM_063267523.1 → XP_063123593.1  leucine-rich repeat flightless-interacting protein 1 isoform X17

    UniProtKB/TrEMBL
    A0A8I5Y0X7
    Related
    ENSRNOP00000076897.1, ENSRNOT00000112051.2

  48. XM_063267528.1 → XP_063123598.1  leucine-rich repeat flightless-interacting protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A8I5ZL04
    Related
    ENSRNOP00000078450.2, ENSRNOT00000112176.2

  49. XM_063267540.1 → XP_063123610.1  leucine-rich repeat flightless-interacting protein 1 isoform X43

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HF9.1 GenPept UniProtKB/Swiss-Prot:Q66HF9

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