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Zfx zinc finger protein X-linked [ Rattus norvegicus (Norway rat) ]

Gene ID: 367832, updated on 2-Nov-2024

Summary

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Official Symbol
Zfxprovided by RGD
Official Full Name
zinc finger protein X-linkedprovided by RGD
Primary source
RGD:1562664
See related
EnsemblRapid:ENSRNOG00000005624 AllianceGenome:RGD:1562664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562664
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including oocyte development; ovarian follicle development; and parental behavior. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be active in chromosome. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 157.2), Lung (RPKM 134.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfx in Genome Data Viewer
Location:
Xq22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (62798483..62847068, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (58804690..58853155, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (63158368..63204971, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Supt20h like 1 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene small nuclear ribonucleoprotein polypeptide F, pseudogene 2 Neighboring gene uncharacterized LOC134484053 Neighboring gene uncharacterized LOC134484164 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Zfx mutation results in small animal size and reduced germ cell number in male and female mice. Luoh SW, et al. Development, 1997 Jun. PMID 9187153
  2. Molecular phylogenetics and the origins of placental mammals. Murphy WJ, et al. Nature, 2001 Feb 1. PMID 11214319
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oocyte development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within parental behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger X-chromosomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109017.3 → NP_001102487.2  zinc finger X-chromosomal protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A096MJI1
    Related
    ENSRNOP00000112832.1, ENSRNOT00000149886.1
    Conserved Domains (6) summary
    COG5048
    Location:537 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713 → 735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727 → 751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371 → 451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    62798483..62847068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280179.1 → XP_063136249.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/TrEMBL
    A0A096MJV6

  2. XM_006257030.5 → XP_006257092.1  zinc finger X-chromosomal protein isoform X1

    See identical proteins and their annotated locations for XP_006257092.1

    UniProtKB/TrEMBL
    A0A096MJI1
    Conserved Domains (6) summary
    COG5048
    Location:537 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713 → 735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727 → 751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371 → 451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  3. XM_039099945.2 → XP_038955873.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/TrEMBL
    A0A096MJI1
    Conserved Domains (6) summary
    COG5048
    Location:537 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713 → 735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727 → 751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371 → 451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  4. XM_063280177.1 → XP_063136247.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/TrEMBL
    A0A096MJV6
    Related
    ENSRNOP00000068277.2, ENSRNOT00000076175.4

  5. XM_063280178.1 → XP_063136248.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/TrEMBL
    A0A096MJV6

  6. XM_039099947.2 → XP_038955875.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/TrEMBL
    A0A096MJI1, A0A096MJV6
    Conserved Domains (6) summary
    COG5048
    Location:487 → 624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434 → 454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:663 → 685
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 354
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:677 → 701
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:321 → 401
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  7. XM_039099946.2 → XP_038955874.1  zinc finger X-chromosomal protein isoform X2

    UniProtKB/TrEMBL
    A0A096MJI1
    Related
    ENSRNOP00000068521.3, ENSRNOT00000076765.3
    Conserved Domains (6) summary
    COG5048
    Location:490 → 627
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:437 → 457
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:666 → 688
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 351
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:680 → 704
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:374 → 404
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  8. XM_006257032.5 → XP_006257094.1  zinc finger X-chromosomal protein isoform X1

    See identical proteins and their annotated locations for XP_006257094.1

    UniProtKB/TrEMBL
    A0A096MJI1
    Conserved Domains (6) summary
    COG5048
    Location:537 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713 → 735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727 → 751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371 → 451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  9. XM_008773265.4 → XP_008771487.1  zinc finger X-chromosomal protein isoform X1

    See identical proteins and their annotated locations for XP_008771487.1

    UniProtKB/TrEMBL
    A0A096MJI1
    Conserved Domains (6) summary
    COG5048
    Location:537 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713 → 735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727 → 751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371 → 451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
Nucleotide Protein Strain
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