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Armcx2 armadillo repeat containing, X-linked 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367903, updated on 19-Sep-2024

Summary

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Official Symbol
Armcx2provided by RGD
Official Full Name
armadillo repeat containing, X-linked 2provided by RGD
Primary source
RGD:1359132
See related
EnsemblRapid:ENSRNOG00000025705 AllianceGenome:RGD:1359132
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human ARMCX2 (armadillo repeat containing X-linked 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 193.5), Uterus (RPKM 59.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Armcx2 in Genome Data Viewer
Location:
Xq32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102273915..102278789, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97980662..97985523, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105617383..105622209, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene armadillo repeat containing, X-linked 3 Neighboring gene cofilin 1, pseudogene 2 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. Kurochkin IV, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162520
  2. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Smith CA, et al. Dev Dyn, 2005 May. PMID 15759267
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
armadillo repeat-containing X-linked protein 2
Names
ALEX2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014274.1 → NP_001014296.1  armadillo repeat-containing X-linked protein 2

    See identical proteins and their annotated locations for NP_001014296.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081886
    UniProtKB/TrEMBL
    A0A8I5ZLU9, D4A765, Q642B5
    Related
    ENSRNOP00000107846.1, ENSRNOT00000169270.1
    Conserved Domains (3) summary
    cd00020
    Location:518 → 600
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:515 → 764
    Arm_2; Armadillo-like
    sd00044
    Location:529 → 554
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    102273915..102278789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773429.4 → XP_008771651.1  armadillo repeat-containing X-linked protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008771651.1

    UniProtKB/TrEMBL
    A0A8I5ZLU9, D4A765, Q642B5
    Related
    ENSRNOP00000030098.5, ENSRNOT00000029511.7
    Conserved Domains (3) summary
    cd00020
    Location:518 → 600
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:515 → 764
    Arm_2; Armadillo-like
    sd00044
    Location:529 → 554
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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