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glo1 glyoxalase 1 [ Danio rerio (zebrafish) ]

Gene ID: 368213, updated on 28-Oct-2024

Summary

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Official Symbol
glo1provided by ZNC
Official Full Name
glyoxalase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030722-9
See related
Ensembl:ENSDARG00000068978 AllianceGenome:ZFIN:ZDB-GENE-030722-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb554; zgc:66035; wu:fb82g09
Summary
Enables lactoylglutathione lyase activity. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and segmental plate. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See glo1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (44788077..44808657, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (44651173..44671753, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene zinc finger, AN1-type domain 3 Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene BTB (POZ) domain containing 9 Neighboring gene oocyte zinc finger protein XlCOF19 Neighboring gene si:dkeyp-2e4.8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signaling cascade. Jörgens K, et al. Diabetes, 2015 Jan. PMID 25092676
  2. Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures. Horzmann KA, et al. J Proteomics, 2018 Aug 30. PMID 30012420, Free PMC Article
  3. Lactate metabolism coordinates macrophage response and regeneration in zebrafish. Bohaud C, et al. Theranostics, 2022. PMID 35664055, Free PMC Article
  4. Analysis of differentially expressed proteins in zebrafish (Danio rerio) embryos exposed to chlorpyrifos. Liu L, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2015 Jan. PMID 25445019
  5. The combination of loss of glyoxalase1 and obesity results in hyperglycemia. Lodd E, et al. JCI Insight, 2019 Jun 20. PMID 31217350, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lactoylglutathione lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lactoylglutathione lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lactoylglutathione lyase
NP_998316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213151.1 → NP_998316.1  lactoylglutathione lyase

    See identical proteins and their annotated locations for NP_998316.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062383
    UniProtKB/TrEMBL
    A0A8M1PIW1, Q6P696
    Related
    ENSDARP00000090756.3, ENSDART00000099984.4
    Conserved Domains (1) summary
    cl14632
    Location:22 → 179
    Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    44788077..44808657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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