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sgce sarcoglycan, epsilon [ Danio rerio (zebrafish) ]

Gene ID: 368230, updated on 2-Nov-2024

Summary

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Official Symbol
sgceprovided by ZNC
Official Full Name
sarcoglycan, epsilonprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030724-1
See related
Ensembl:ENSDARG00000012138 AllianceGenome:ZFIN:ZDB-GENE-030724-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
scge; zgc:92318
Summary
Predicted to enable calcium ion binding activity. Predicted to be located in several cellular components, including Golgi apparatus; dendrite; and sarcolemma. Predicted to be part of sarcoglycan complex. Is expressed in central nervous system; retina; retinal ganglion cell layer; and retinal inner nuclear layer. Human ortholog(s) of this gene implicated in myoclonic dystonia 11. Orthologous to human SGCE (sarcoglycan epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See sgce in Genome Data Viewer
Location:
chromosome: 19
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (41031265..41069577, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (41451542..41482486, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488548 Neighboring gene collagen, type I, alpha 2 Neighboring gene CAS1 domain containing 1 Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene ankyrin repeat and SOCS box containing 4 Neighboring gene pyruvate dehydrogenase kinase, isozyme 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sarcoglycans of the zebrafish: orthology and localization to the sarcolemma and myosepta of muscle. Chambers SP, et al. Biochem Biophys Res Commun, 2003 Apr 4. PMID 12659844
  2. Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. Rodius S, et al. BMC Genomics, 2014 Oct 3. PMID 25280539, Free PMC Article
  3. Zebrafish orthologs of human muscular dystrophy genes. Steffen LS, et al. BMC Genomics, 2007 Mar 20. PMID 17374169, Free PMC Article
  4. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923
  5. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of sarcoglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sarcoglycan complex IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
epsilon-sarcoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002594.1 → NP_001002594.1  epsilon-sarcoglycan precursor

    See identical proteins and their annotated locations for NP_001002594.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076003
    UniProtKB/TrEMBL
    A0A8M1N0X7, Q6DHH1
    Related
    ENSDARP00000099762.2, ENSDART00000111982.4
    Conserved Domains (1) summary
    pfam05510
    Location:10 → 396
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    41031265..41069577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159717.5 → XP_005159774.1  epsilon-sarcoglycan isoform X4

    UniProtKB/TrEMBL
    A0A8M2B6H2
    Conserved Domains (1) summary
    pfam05510
    Location:10 → 396
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  2. XM_017352192.3 → XP_017207681.2  epsilon-sarcoglycan isoform X5

    UniProtKB/TrEMBL
    A0A8M6YTU0
    Conserved Domains (1) summary
    pfam05510
    Location:42 → 414
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  3. XM_017352190.3 → XP_017207679.2  epsilon-sarcoglycan isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z2W7
    Conserved Domains (1) summary
    pfam05510
    Location:42 → 414
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  4. XM_021468003.2 → XP_021323678.1  epsilon-sarcoglycan isoform X3

    UniProtKB/TrEMBL
    A0A8M9PAU2
    Conserved Domains (1) summary
    pfam05510
    Location:42 → 423
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  5. XM_021468002.2 → XP_021323677.1  epsilon-sarcoglycan isoform X1

    UniProtKB/TrEMBL
    A0A8M9P1Q4
    Conserved Domains (1) summary
    pfam05510
    Location:42 → 423
    Sarcoglycan_2; Sarcoglycan alpha/epsilon
Nucleotide Protein
Heading Accession and Version

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