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plp1b proteolipid protein 1b [ Danio rerio (zebrafish) ]

Gene ID: 368234, updated on 28-Oct-2024

Summary

Official Symbol
plp1bprovided by ZNC
Official Full Name
proteolipid protein 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030710-6
See related
Ensembl:ENSDARG00000011929 AllianceGenome:ZFIN:ZDB-GENE-030710-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fv76c02; DMalpha2a; DMalpha2b; DMalpha2c; zgc:91786; wu:fv76c02
Summary
Predicted to be a structural constituent of myelin sheath. Predicted to be involved in axon development and central nervous system myelination. Predicted to be located in membrane. Predicted to be active in myelin sheath and plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See plp1b in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23268121..23280156, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22764320..22776361, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-125i10.3 Neighboring gene angiotensin II receptor, type 2 Neighboring gene neuroligin 3b Neighboring gene glutamate receptor, ionotropic, AMPA 3a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in central nervous system myelination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
proteolipid protein 1b
Names
dm20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005586.2NP_001005586.1  proteolipid protein 1b

    See identical proteins and their annotated locations for NP_001005586.1

    Status: PROVISIONAL

    Source sequence(s)
    AY070263
    UniProtKB/TrEMBL
    Q642I0, Q8UUT2
    Related
    ENSDARP00000002599.6, ENSDART00000003514.8
    Conserved Domains (1) summary
    pfam01275
    Location:15252
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    23268121..23280156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165123.5XP_005165180.1  proteolipid protein 1b isoform X2

    See identical proteins and their annotated locations for XP_005165180.1

    UniProtKB/TrEMBL
    A0A8M2BCG8, Q8UUT3
    Related
    ENSDARP00000051532.6, ENSDART00000051533.8
    Conserved Domains (1) summary
    pfam01275
    Location:37274
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  2. XM_005165122.5XP_005165179.1  proteolipid protein 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCB3
    Conserved Domains (1) summary
    pfam01275
    Location:38275
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
  3. XM_005165124.5XP_005165181.1  proteolipid protein 1b isoform X3

    See identical proteins and their annotated locations for XP_005165181.1

    UniProtKB/TrEMBL
    A0A8M2BCD0, Q8UUT5
    Related
    ENSDARP00000104662.2, ENSDART00000126540.3
    Conserved Domains (1) summary
    pfam01275
    Location:3240
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)