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celsr1a cadherin EGF LAG seven-pass G-type receptor 1a [ Danio rerio (zebrafish) ]

Gene ID: 368436, updated on 25-Apr-2024

Summary

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Official Symbol
celsr1aprovided by ZNC
Official Full Name
cadherin EGF LAG seven-pass G-type receptor 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-78
See related
Ensembl:ENSDARG00000069185 AllianceGenome:ZFIN:ZDB-GENE-030616-78
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
EGF; LAG; frnt; CELSR; fmi1a; celsr1; zfmi1a; fb15b11; bZ22E02.1; wu:fb15b11; si:bz6l08.1
Summary
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within cell migration involved in gastrulation; heart development; and neural tube development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; germ ring; heart; optic primordium; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See celsr1a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
36
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (28191612..28335364, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (28202324..28346070, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene ceramide kinase Neighboring gene GRAM domain containing 4a Neighboring gene tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase Neighboring gene serine racemase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Qiao X, et al. Clin Sci (Lond), 2016 Dec 1. PMID 27756857
  2. Celsr family genes are dynamically expressed in embryonic and juvenile zebrafish. Joshi B, et al. Dev Neurobiol, 2022 Mar. PMID 35213071
  3. Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. Witzel S, et al. J Cell Biol, 2006 Dec 4. PMID 17130287, Free PMC Article
  4. Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Wada H, et al. Development, 2006 Dec. PMID 17079269
  5. Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. Carreira-Barbosa F, et al. Development, 2009 Feb. PMID 19091770, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.
    Title: celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish.
  2. Fmi/Celsr therefore has a dual role in mediating two separate morphogenetic movements through its roles in mediating cell cohesion and Wnt/PCP signalling during zebrafish gastrulation.
    Title: Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural tube development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cadherin EGF LAG seven-pass G-type receptor 1; cadherin EGF LAG seven-pass G-type receptor 1a
Names
celsr4
flamingo 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    28191612..28335364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009300462.3 → XP_009298737.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3ARU0
    Related
    ENSDARP00000143939.1, ENSDART00000178149.2
    Conserved Domains (12) summary
    cd11304
    Location:578 → 675
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2042 → 2103
    HormR; Domain present in hormone receptors
    smart00180
    Location:1993 → 2038
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1355 → 1390
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1435 → 1618
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:1915 → 1975
    TNFRSF; CRD2 [structural motif]
    pfam00002
    Location:2447 → 2675
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam00008
    Location:1644 → 1674
    EGF; EGF-like domain
    pfam01825
    Location:2390 → 2435
    GPS; GPCR proteolysis site, GPS, motif
    pfam02210
    Location:1710 → 1842
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:2121 → 2360
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:1874 → 2028
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. XM_009300461.3 → XP_009298736.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3B933
    Conserved Domains (12) summary
    cd11304
    Location:578 → 675
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2069 → 2130
    HormR; Domain present in hormone receptors
    smart00180
    Location:2020 → 2065
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1355 → 1390
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1435 → 1645
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:1942 → 2002
    TNFRSF; CRD2 [structural motif]
    pfam00002
    Location:2474 → 2702
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam00008
    Location:1671 → 1701
    EGF; EGF-like domain
    pfam01825
    Location:2417 → 2462
    GPS; GPCR proteolysis site, GPS, motif
    pfam02210
    Location:1737 → 1869
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:2148 → 2387
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:1901 → 2055
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  3. XM_009300460.3 → XP_009298735.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ARK0
    Conserved Domains (12) summary
    cd11304
    Location:578 → 675
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2069 → 2130
    HormR; Domain present in hormone receptors
    smart00180
    Location:2020 → 2065
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1355 → 1390
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1435 → 1645
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:1942 → 2002
    TNFRSF; CRD2 [structural motif]
    pfam00002
    Location:2474 → 2702
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam00008
    Location:1671 → 1701
    EGF; EGF-like domain
    pfam01825
    Location:2417 → 2462
    GPS; GPCR proteolysis site, GPS, motif
    pfam02210
    Location:1737 → 1869
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:2148 → 2387
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:1901 → 2055
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  4. XM_005168547.4 → XP_005168604.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFV5, F1R9W4
    Related
    ENSDARP00000043736.5, ENSDART00000043737.5
    Conserved Domains (12) summary
    cd11304
    Location:578 → 675
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2069 → 2130
    HormR; Domain present in hormone receptors
    smart00180
    Location:2020 → 2065
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00054
    Location:1355 → 1390
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:1435 → 1645
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:1942 → 2002
    TNFRSF; CRD2 [structural motif]
    pfam00002
    Location:2474 → 2702
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam00008
    Location:1671 → 1701
    EGF; EGF-like domain
    pfam01825
    Location:2417 → 2462
    GPS; GPCR proteolysis site, GPS, motif
    pfam02210
    Location:1737 → 1869
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:2148 → 2387
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:1901 → 2055
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein Strain
Heading Accession and Version

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