cntfr ciliary neurotrophic factor receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cntfrprovided by ZNC
Official Full Name: ciliary neurotrophic factor receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-82
See related: Ensembl:ENSDARG00000028661 AllianceGenome:ZFIN:ZDB-GENE-030616-82
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb549; fj33e02; sb:cb549; wu:fj33e02; si:bz76a6.1; si:dz248f2.1; si:rp71-76a6.1
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Acts upstream of or within positive regulation of axon regeneration. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; cranial ganglion; hindbrain neural plate; immature eye; and pectoral fin musculature. Orthologous to human CNTFR (ciliary neurotrophic factor receptor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (13460134..13772870, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (13502011..13814728, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb77h01.y1 (e-PCR)
- UniSTS:191392

fj33e02.x1 (e-PCR)
- UniSTS:199114

fb81c05.x1 (e-PCR)
- UniSTS:187628

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ciliary neurotrophic factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ciliary neurotrophic factor receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098242.2 → NP_001091712.1 ciliary neurotrophic factor receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_001091712.1

Status: VALIDATED

Source sequence(s)

DN899643, EB838570, EB944917, EB990448, EE304079, EH536767

UniProtKB/TrEMBL

A0A8M1NDI9, A4JYQ0

Related

ENSDARP00000114970.1, ENSDART00000145103.3

Conserved Domains (3) summary

cd00063
Location:203 → 299

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:38 → 94

Ig; Immunoglobulin domain

cl21522
Location:107 → 187

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...