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ctsc cathepsin C [ Danio rerio (zebrafish) ]

Gene ID: 368704, updated on 2-Nov-2024

Summary

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Official Symbol
ctscprovided by ZNC
Official Full Name
cathepsin Cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030619-9
See related
Ensembl:ENSDARG00000101334 AllianceGenome:ZFIN:ZDB-GENE-030619-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb912; sb:cb146; wu:fb34g12; wu:fj58d01; ik:tdsubc_1h2
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Is expressed in macrophage; neural crest; polster; somite; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ctsc in Genome Data Viewer
Location:
chromosome: 15
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (43604031..43625549, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (43682954..43704472)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene actinin, alpha 4 Neighboring gene RAB38a, member RAS oncogene family Neighboring gene glutamate receptor, metabotropic 5b Neighboring gene tyrosinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker. Che R, et al. Fish Shellfish Immunol, 2014 Dec. PMID 25181651
  2. Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme. Tingaud-Sequeira A, et al. Gene, 2007 Jan 15. PMID 17027199
  3. An anti-inflammatory NOD-like receptor is required for microglia development. Shiau CE, et al. Cell Rep, 2013 Dec 12. PMID 24316075, Free PMC Article
  4. Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation. Hartig EI, et al. Biol Open, 2016 Aug 15. PMID 27444789, Free PMC Article
  5. Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. Wang Z, et al. BMC Genomics, 2010 Jun 22. PMID 20565988, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dipeptidyl peptidase 1
NP_999887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214722.1 → NP_999887.1  dipeptidyl peptidase 1 precursor

    See identical proteins and their annotated locations for NP_999887.1

    Status: PROVISIONAL

    Source sequence(s)
    BC064286
    UniProtKB/TrEMBL
    Q6P2V1
    Related
    ENSDARP00000135284.2, ENSDART00000168589.2
    Conserved Domains (2) summary
    cd02621
    Location:224 → 452
    Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
    pfam08773
    Location:20 → 132
    CathepsinC_exc; Cathepsin C exclusion domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    43604031..43625549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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