si:busm1-194e12.8 si:busm1-194e12.8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: si:busm1-194e12.8provided by ZNC
Official Full Name: si:busm1-194e12.8provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-323
See related: Ensembl:ENSDARG00000103702 AllianceGenome:ZFIN:ZDB-GENE-030616-323
Gene type: protein coding
RefSeq status: PREDICTED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MHCII; zgc:101701; si:dz194e12.8; si:dz160c18.10; si:busm1-160c18.10
Summary: Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within adaptive immune response and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and systemic scleroderma (multiple). Orthologous to human HLA-DOA (major histocompatibility complex, class II, DO alpha) and HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See si:busm1-194e12.8 in Genome Data Viewer

Location:: chromosome: 8

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (36416298..36421114)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (36383864..36388680)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein LOC368816

Names: MHC class II; alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007429.1 → NP_001007430.1 uncharacterized protein LOC368816 precursor

See identical proteins and their annotated locations for NP_001007430.1

Status: PREDICTED

Source sequence(s)

BC085418

UniProtKB/TrEMBL

Q5U3R9

Related

ENSDARP00000134462.1, ENSDART00000158400.2

Conserved Domains (2) summary

pfam00993
Location:22 → 99

MHC_II_alpha; Class II histocompatibility antigen, alpha domain

cl11960
Location:103 → 197

Ig; Immunoglobulin domain