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mhc2daa major histocompatibility complex class II DAA gene [ Danio rerio (zebrafish) ]

Gene ID: 368878, updated on 15-Jun-2024

Summary

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Official Symbol
mhc2daaprovided by ZNC
Official Full Name
major histocompatibility complex class II DAA geneprovided by ZNC
Primary source
ZFIN:ZDB-GENE-980526-201
See related
Ensembl:ENSDARG00000031745 AllianceGenome:ZFIN:ZDB-GENE-980526-201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
a1; a2; MHCII; mhcdaa; wu:fa93a04; zgc:103599; zgc:113853; zgc:113912; si:dz266f07.2; si:busm1-266f07.2
Orthologs
all
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Genomic context

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See mhc2daa in Genome Data Viewer
Location:
chromosome: 8
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (36472444..36475328, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (36440010..36442894, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:busm1-194e12.8 Neighboring gene major histocompatibility complex class II DAB gene Neighboring gene solute carrier family 7 member 4 Neighboring gene coiled-coil domain containing 157

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish Mhc class II alpha chain-encoding genes: polymorphism, expression, and function. Sültmann H, et al. Immunogenetics, 1993. PMID 8406613
  2. Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning. Hess I, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431192, Free PMC Article
  3. Essential role of IL-4 and IL-4Rα interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates. Zhu LY, et al. J Immunol, 2012 Jun 1. PMID 22547699
  4. Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates. Dijkstra JM, et al. BMC Evol Biol, 2013 Nov 26. PMID 24279922, Free PMC Article
  5. RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Wu XM, et al. Front Immunol, 2018. PMID 29692779, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC103599, MGC113853, MGC113912, MGC192244

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major histocompatibility complex class II DAA
Names
MHC class II integral membrane protein alpha chain 1
MHC class II integral membrane protein alpha chain 2
alpha chain
major histocompatibility complex DAA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004521.3 → NP_001004521.3  major histocompatibility complex class II DAA precursor

    Status: VALIDATED

    Source sequence(s)
    CU694380, EH471567, EH496041, EH497754
    UniProtKB/TrEMBL
    Q1MTC7, Q4KM20
    Related
    ENSDARP00000048447.7, ENSDART00000048448.9
    Conserved Domains (2) summary
    smart00920
    Location:21 → 99
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cl11960
    Location:103 → 197
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    36472444..36475328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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