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ITGB2 integrin subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 3689, updated on 10-Dec-2024

Summary

Official Symbol
ITGB2provided by HGNC
Official Full Name
integrin subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:6155
See related
Ensembl:ENSG00000160255 MIM:600065; AllianceGenome:HGNC:6155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Summary
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Broad expression in bone marrow (RPKM 117.8), appendix (RPKM 80.8) and 14 other tissues See more
Orthologs
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Genomic context

See ITGB2 in Genome Data Viewer
Location:
21q22.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44885953..44928815, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (43246634..43289593, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46305868..46348730, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr21:46227083-46227236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46235315-46235829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13391 Neighboring gene small ubiquitin like modifier 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46243688-46244247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46254495-46254996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46265244-46265744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46265745-46266245 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46282185-46282898 Neighboring gene PTTG1 interacting protein Neighboring gene uncharacterized LOC124905039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18578 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46292726-46293226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46293227-46293727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46293885-46294562 Neighboring gene Sharpr-MPRA regulatory region 2317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46317333-46317948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46326258-46326823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46326824-46327388 Neighboring gene uncharacterized LOC107987303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46329075-46329574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46333656-46334156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46337409-46338321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13395 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46345923-46346812 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:46347045-46348244 Neighboring gene ITGB2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46351267-46352146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13396 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46359630-46360194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18584 Neighboring gene long intergenic non-protein coding RNA 1547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46369323-46369908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46369909-46370494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46371986-46372936 Neighboring gene SLX9 ribosome biogenesis factor Neighboring gene FAM207A intron CAGE-defined mid-level expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46389870-46390685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46390686-46391500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46398896-46399794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46399795-46400691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46406949-46407903 Neighboring gene long intergenic non-protein coding RNA 163

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with integrin, beta 2 (ITGB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
env Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1 PubMed
env HIV-1 gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/beta 2 integrin-dependent fashion PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ITGB2 (CD18); predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
env HIV-1 gp160 is identified to have a physical interaction with integrin, beta 2 (ITGB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins PubMed
tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
tat HIV-1 Tat inhibits calcium influx and impairs CAMKII activation elicited via LFA-1 (beta 2 integrin) in NK cells PubMed
tat HIV-1 Tat treatment of monocytes upregulates beta 2 integrins and anti-beta 2 Abs inhibits Tat induced adhesion of monocytes to endothelial monolayers, suggesting a mechanism where monocytes could be inappropriately activated by HIV-1 Tat PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, beta 2 (ITGB2, complement component 3 receptor 3 and 4) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ICAM-3 receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cell adhesion molecule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables complement component C3b binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables integrin binding TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular extravasation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in leukocyte cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte migration involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of dopamine metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neutrophil degranulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of prostaglandin-E synthase activity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein targeting to membrane NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of superoxide anion generation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of superoxide anion generation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell shape NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface HDA PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular vesicle HDA PubMed 
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin alphaL-beta2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alphaL-beta2 complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of integrin alphaM-beta2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of integrin alphaM-beta2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of integrin alphaX-beta2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of integrin alphaX-beta2 complex TAS
Traceable Author Statement
more info
PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
integrin beta-2
Names
cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)
complement component 3 receptor 3 and 4 subunit
complement receptor C3 beta-subunit
integrin beta chain, beta 2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
leukocyte cell adhesion molecule CD18
leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007270.2 RefSeqGene

    Range
    4966..47886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_76

mRNA and Protein(s)

  1. NM_000211.5NP_000202.3  integrin beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000202.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK095992, AK222505, CA447686, M15395
    Consensus CDS
    CCDS13716.1
    UniProtKB/Swiss-Prot
    B3KTS8, D3DSM1, P05107, Q16418, Q53HS5, Q9UD72
    UniProtKB/TrEMBL
    A0A494C0X7, A0AAA9WZN5
    Related
    ENSP00000498780.1, ENST00000652462.1
    Conserved Domains (3) summary
    smart00187
    Location:32447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622699
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:726767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
  2. NM_001127491.3NP_001120963.2  integrin beta-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001120963.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK095992, AL844908, CA447686, M15395
    Consensus CDS
    CCDS13716.1
    UniProtKB/Swiss-Prot
    B3KTS8, D3DSM1, P05107, Q16418, Q53HS5, Q9UD72
    UniProtKB/TrEMBL
    A0A494C0X7, A0AAA9WZN5
    Related
    ENSP00000347279.4, ENST00000355153.8
    Conserved Domains (3) summary
    smart00187
    Location:32447
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:622699
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:726767
    Integrin_b_cyt; Integrin beta cytoplasmic domain
  3. NM_001303238.2NP_001290167.1  integrin beta-2 isoform 2

    See identical proteins and their annotated locations for NP_001290167.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a shorter 5' UTR, uses an alternate splice site in the 5' region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK303488, AU279404, CA447686, M15395
    UniProtKB/TrEMBL
    A0AAA9WZN5, B4E0R1
    Conserved Domains (3) summary
    smart00187
    Location:1378
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:553630
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:657697
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44885953..44928815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724001.3XP_006724064.1  integrin beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006724064.1

    UniProtKB/TrEMBL
    A0AAA9WZN5, B4E0R1
    Conserved Domains (3) summary
    smart00187
    Location:1378
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:553630
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:657697
    Integrin_b_cyt; Integrin beta cytoplasmic domain
  2. XM_047440763.1XP_047296719.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9WZN5, B4E0R1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    43246634..43289593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324468.1XP_054180443.1  integrin beta-2 isoform X1

    UniProtKB/TrEMBL
    A0AAA9WZN5, B4E0R1