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rab3gap2 RAB3 GTPase activating protein subunit 2 (non-catalytic) [ Danio rerio (zebrafish) ]

Gene ID: 368905, updated on 28-Oct-2024

Summary

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Official Symbol
rab3gap2provided by ZNC
Official Full Name
RAB3 GTPase activating protein subunit 2 (non-catalytic)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-610
See related
Ensembl:ENSDARG00000044136 AllianceGenome:ZFIN:ZDB-GENE-030616-610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
RAB3; RAB3GAP; wu:fb94b08; zgc:158161; si:zc214p16.5; si:ch211-214p16.5
Summary
Predicted to enable small GTPase binding activity. Predicted to contribute to enzyme regulator activity. Predicted to be involved in establishment of protein localization to endoplasmic reticulum membrane; macroautophagy; and synaptic signaling. Predicted to be located in cytoplasm. Predicted to be active in autophagosome and presynaptic membrane. Human ortholog(s) of this gene implicated in Martsolf syndrome and Warburg micro syndrome 2. Orthologous to human RAB3GAP2 (RAB3 GTPase activating non-catalytic protein subunit 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See rab3gap2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (25610350..25630837, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (25591960..25612469, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:ch211-214p16.2 Neighboring gene isoleucyl-tRNA synthetase 2, mitochondrial Neighboring gene protein phosphatase 1, catalytic subunit, beta isozyme Neighboring gene phospholipase B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin. Luo H, et al. Front Cell Dev Biol, 2021. PMID 34733844, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC158161

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in establishment of protein localization to endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rab3 GTPase-activating protein non-catalytic subunit
Names
GTPase-activating

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004528.1 → NP_001004528.1  rab3 GTPase-activating protein non-catalytic subunit

    Status: PROVISIONAL

    Source sequence(s)
    AL929207
    UniProtKB/TrEMBL
    A0A8M1N224, Q7ZYZ0
    Related
    ENSDARP00000096276.2, ENSDART00000105503.4
    Conserved Domains (2) summary
    pfam14655
    Location:74 → 483
    RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus
    pfam14656
    Location:731 → 1247
    RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    25610350..25630837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017351602.3 → XP_017207091.1  rab3 GTPase-activating protein non-catalytic subunit isoform X2

    UniProtKB/TrEMBL
    A0A8M6YVK1, K7DYN0
    Related
    ENSDARP00000126559.1, ENSDART00000151878.2

  2. XM_017351601.3 → XP_017207090.1  rab3 GTPase-activating protein non-catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A8M6YTS4
Nucleotide Protein
Heading Accession and Version

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