tshz1 teashirt zinc finger homeobox 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tshz1provided by ZNC
Official Full Name: teashirt zinc finger homeobox 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030820-3
See related: Ensembl:ENSDARG00000005026 AllianceGenome:ZFIN:ZDB-GENE-030820-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tsh1; tsrt; tshz1a; sdccag33
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; head; hindbrain neural plate; neural tube; and pectoral fin bud. Orthologous to human TSHZ1 (teashirt zinc finger homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (21366065..21413560)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (21780541..21829237)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of tsh1 (homologue of Drosophila homeotic gene teashirt) is detected at the 2-somite stage at the anterior end of the spinal cord, expression then expands and by the prim-5 stage tsh1 transcripts are detected throughout spinal cord.
Title: Isolation and expression of zebrafish zinc-finger transcription factor gene tsh1.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: teashirt homolog 1

Names: serologically defined colon cancer antigen 33; teashirt family zinc finger 1; teashirt-like zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042746.1 → NP_001036211.1 teashirt homolog 1

See identical proteins and their annotated locations for NP_001036211.1

Status: VALIDATED

Source sequence(s)

BX470238

UniProtKB/Swiss-Prot

B3DJM5, Q8QGQ9

Related

ENSDARP00000148441.1, ENSDART00000186194.1

Conserved Domains (2) summary

cd00086
Location:964 → 1032

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:290 → 312

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

21366065..21413560

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068215044.1 → XP_068071145.1 teashirt homolog 1 isoform X1

Related

ENSDARP00000105499.3, ENSDART00000122002.4
XM_009294201.4 → XP_009292476.1 teashirt homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8M3AVH8, F6NU84

Conserved Domains (2) summary

cd00086
Location:945 → 1013

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00020
Location:271 → 293

ZF_C2H2; C2H2 Zn finger [structural motif]