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Dcr-2 Dicer-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36993, updated on 24-Oct-2024

Summary

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Official Symbol
Dcr-2provided by FlyBase
Official Full Name
Dicer-2provided by FlyBase
Primary source
FLYBASE:FBgn0034246
Locus tag
Dmel_CG6493
See related
AllianceGenome:FB:FBgn0034246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg6493; CG6493; dcr; Dcr; dcr-2; DCR-2; dcr2; Dcr2; DCR2; dDcr2; dic2; dicer; Dicer; DICER; dicer-2; DICER-2; Dicer-II; dicer2; Dicer2; dmDcr-2; DmDcr-2; Dmel\CG6493
Summary
Enables ATP-dependent activity, acting on RNA; RNA binding activity; and bidentate ribonuclease III activity. Involved in several processes, including gene silencing by RNA; regulation of defense response; and response to virus. Located in cytoplasm and nucleus. Part of RISC complex and RISC-loading complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Dcr-2 in Genome Data Viewer
Location:
54C10-54C10; 2-83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17574979..17581525, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13462484..13469030, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rab4 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45274

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies. Alic N, et al. PLoS One, 2012. PMID 23028964, Free PMC Article
  2. The RNAi pathway initiated by Dicer-2 in Drosophila. Kim K, et al. Cold Spring Harb Symp Quant Biol, 2006. PMID 17381278
  3. Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self-nonself discrimination. Singh RK, et al. Elife, 2021 Mar 31. PMID 33787495, Free PMC Article
  4. Antisense Transcription of Retrotransposons in Drosophila: An Origin of Endogenous Small Interfering RNA Precursors. Russo J, et al. Genetics, 2016 Jan. PMID 26534950, Free PMC Article
  5. Parallel evolution and enhanced virulence upon in vivo passage of an RNA virus in Drosophila melanogaster. Lezcano OM, et al. Virus Evol, 2023. PMID 38162315, Free PMC Article

See all (597) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers.
    Title: Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers.
  2. Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD.
    Title: Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD.
  3. Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.
    Title: Structure of the Dicer-2-R2D2 heterodimer bound to a small RNA duplex.
  4. Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self-nonself discrimination.
    Title: Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self-nonself discrimination.
  5. TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity.
    Title: TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity.
  6. mutating Dicer-2 results in enhanced Zika virus load and increased susceptibility to Zika virus infection
    Title: Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection in Drosophila.
  7. The results uncover a novel function of Dicer-2 in activation of mRNA translation through cytoplasmic polyadenylation.
    Title: Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation.
  8. studies indicate that the 22 amino acids at the C terminus of Loqs-PD, including an FDF-like motif, directly interact with the Hel2 subdomain of Dicer-2's helicase domain. This interaction is RNA-independent, but we find that modulation of Dicer-2 cleavage also requires dsRNA binding by Loqs-PD.
    Title: Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA.
  9. this study used cryo-electron microscopy to solve structures of Drosophila Dicer-2 alone and in complex with blunt dsRNA.
    Title: Dicer uses distinct modules for recognizing dsRNA termini.
  10. Loqs-PD removes the inhibitory effect of inorganic phosphate on Dicer-2 processing of blunt-end hairpin RNAs, allowing siRNA production in the presence of inorganic phosphate.
    Title: Loquacious-PD removes phosphate inhibition of Dicer-2 processing of hairpin RNAs into siRNAs.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent activity, acting on RNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables deoxyribonuclease I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease III activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonuclease III activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables siRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RISC complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RISC complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNAi-mediated antiviral immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dosage compensation by hyperactivation of X chromosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dsRNA transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in global gene silencing by mRNA cleavage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lncRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Toll signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in pre-miRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in siRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RISC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RISC-loading complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RISC-loading complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RISC-loading complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of RISC-loading complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dicer-2
Names
CG6493-PA
CG6493-PB
Dcr-2-PA
Dcr-2-PB
Dicer2
dicer
dicer 2
dicer-2
NP_001286540.1
NP_523778.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17574979..17581525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299611.1 → NP_001286540.1  Dicer-2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286540.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFK8, Q2Q3W0
    Conserved Domains (9) summary
    smart00490
    Location:438 → 495
    HELICc; helicase superfamily c-terminal domain
    smart00949
    Location:842 → 1003
    PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
    COG0571
    Location:1432 → 1718
    Rnc; dsRNA-specific ribonuclease [Transcription]
    COG1111
    Location:6 → 542
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:22 → 173
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:1447 → 1648
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd15903
    Location:241 → 343
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00035
    Location:1652 → 1716
    dsrm; Double-stranded RNA binding motif
    pfam03368
    Location:572 → 665
    Dicer_dimer; Dicer dimerization domain

  2. NM_079054.5 → NP_523778.2  Dicer-2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523778.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZAW0, Q95YG3
    UniProtKB/TrEMBL
    Q2Q3W0
    Related
    FBpp0086061
    Conserved Domains (9) summary
    smart00490
    Location:438 → 495
    HELICc; helicase superfamily c-terminal domain
    smart00949
    Location:843 → 1004
    PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
    COG0571
    Location:1433 → 1719
    Rnc; dsRNA-specific ribonuclease [Transcription]
    COG1111
    Location:6 → 542
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:22 → 173
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00593
    Location:1448 → 1649
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd15903
    Location:241 → 343
    Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    pfam00035
    Location:1653 → 1717
    dsrm; Double-stranded RNA binding motif
    pfam03368
    Location:572 → 665
    Dicer_dimer; Dicer dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFK8 A0A0B4LFK8
A1ZAW0.1 A1ZAW0
Q2Q3V4 Q2Q3V4
Q2Q3V5 Q2Q3V5
Q2Q3V6 Q2Q3V6
Q2Q3V7 Q2Q3V7
Q2Q3V8 Q2Q3V8
Q2Q3V9 Q2Q3V9
Q2Q3W0 Q2Q3W0
Q2Q3W1 Q2Q3W1

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