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gys2 glycogen synthase 2 [ Danio rerio (zebrafish) ]

Gene ID: 373082, updated on 2-Nov-2024

Summary

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Official Symbol
gys2provided by ZNC
Official Full Name
glycogen synthase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030826-31
See related
Ensembl:ENSDARG00000004904 AllianceGenome:ZFIN:ZDB-GENE-030826-31
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb765; zgc:112057
Summary
Predicted to enable alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Predicted to be involved in glycogen biosynthetic process and response to glucose. Predicted to be located in cortical actin cytoskeleton and cytosol. Predicted to be active in cytoplasm. Is expressed in hepatocyte; liver; male organism; and muscle. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gys2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (16800017..16827999, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (16811046..16835348, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene golgi transport 1Ba Neighboring gene spexin hormone Neighboring gene kisspeptin 2 Neighboring gene lactate dehydrogenase Ba Neighboring gene solute carrier family 25 member 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus. Liu Y, et al. Mol Cell Endocrinol, 2013 Jul 15. PMID 23623870
  2. Quantitative Phosphoproteomic Analysis Reveals the Regulatory Networks of Elovl6 on Lipid and Glucose Metabolism in Zebrafish. Wang X, et al. Int J Mol Sci, 2020 Apr 19. PMID 32325903, Free PMC Article
  3. Loss of the RNA-binding protein Rbm15 disrupts liver maturation in zebrafish. Hu L, et al. J Biol Chem, 2020 Aug 14. PMID 32518161, Free PMC Article
  4. Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish. Houbrechts AM, et al. Endocrinology, 2019 Nov 1. PMID 31504428
  5. Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish. Ding Q, et al. Front Nutr, 2022. PMID 35685883, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cortical actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glycogen [starch] synthase, liver
NP_001018199.1
XP_068075632.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018679.1 → NP_001018199.1  glycogen [starch] synthase, liver

    See identical proteins and their annotated locations for NP_001018199.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095660
    UniProtKB/TrEMBL
    Q502K7, Q5RGX8
    Related
    ENSDARP00000002983.7, ENSDART00000014007.8
    Conserved Domains (2) summary
    cd03793
    Location:27 → 616
    GT1_Glycogen_synthase_GSY2_like; Glycogen synthase, which is most closely related to the GT1 family of glycosyltransferases, catalyzes the transfer of a glucose molecule from UDP-glucose to a terminal branch of a glycogen molecule, a rate-limit step of glycogen biosynthesis. GSY2, the ...
    pfam05693
    Location:32 → 655
    Glycogen_syn; Glycogen synthase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    16800017..16827999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068219531.1 → XP_068075632.1  glycogen [starch] synthase, liver isoform X1

Nucleotide Protein
Heading Accession and Version

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