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tjp3 tight junction protein 3 [ Danio rerio (zebrafish) ]

Gene ID: 373089, updated on 12-Sep-2024

Summary

Official Symbol
tjp3provided by ZNC
Official Full Name
tight junction protein 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030828-10
See related
Ensembl:ENSDARG00000002909 AllianceGenome:ZFIN:ZDB-GENE-030828-10
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zo-3; cb766; wu:fj93c08
Summary
Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within multicellular organismal homeostasis and water homeostasis. Located in bicellular tight junction. Is expressed in several structures, including digestive system; integument; mesoderm; pleuroperitoneal region; and sensory system. Orthologous to human TJP3 (tight junction protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See tjp3 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (17657601..17688868, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (17632519..17663890, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 45b Neighboring gene RNA polymerase II, I and III subunit E, b Neighboring gene strawberry notch homolog 2b Neighboring gene transmembrane 6 superfamily member 2b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of endothelial intestinal barrier IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organismal-level homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal-level water homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood-brain barrier permeability IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tight junction protein ZO-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328340.1NP_001315269.1  tight junction protein ZO-3

    Status: VALIDATED

    Source sequence(s)
    CU695074, CU856138
    UniProtKB/TrEMBL
    A0A8M2BHQ8, F1R3X0
    Related
    ENSDARP00000025259.10, ENSDART00000012336.10
    Conserved Domains (6) summary
    COG0265
    Location:652704
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:1095
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:632700
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam05750
    Location:444565
    Rubella_Capsid; Rubella capsid protein
    cl17036
    Location:725789
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8311005
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    17657601..17688868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170442.5XP_005170499.1  tight junction protein ZO-3 isoform X1

    See identical proteins and their annotated locations for XP_005170499.1

    UniProtKB/TrEMBL
    A0A8M2BHQ8, F1R3X0
    Conserved Domains (6) summary
    COG0265
    Location:652704
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:1095
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:632700
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam05750
    Location:444565
    Rubella_Capsid; Rubella capsid protein
    cl17036
    Location:725789
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:8311005
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201494.1: Suppressed sequence

    Description
    NM_201494.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.