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casp2 caspase 2, apoptosis-related cysteine peptidase [ Danio rerio (zebrafish) ]

Gene ID: 373118, updated on 2-Nov-2024

Summary

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Official Symbol
casp2provided by ZNC
Official Full Name
caspase 2, apoptosis-related cysteine peptidaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030825-3
See related
Ensembl:ENSDARG00000062052 AllianceGenome:ZFIN:ZDB-GENE-030825-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of apoptotic process; and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be active in cytoplasm. Is expressed in digestive system; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human CASP2 (caspase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See casp2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (17550229..17578432, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (17642100..17670484, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 131 member Bb Neighboring gene chloride channel, voltage-sensitive 1b Neighboring gene uncharacterized LOC137487837 Neighboring gene mannose-6-phosphate receptor (cation dependent)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish. Eğimezer G, et al. Hum Exp Toxicol, 2020 Jul. PMID 32054343
  2. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures. Luzio A, et al. Aquat Toxicol, 2016 Aug. PMID 27337697
  3. The cellular responses of autophagy, apoptosis, and 5-methylcytosine level in zebrafish cells upon nutrient deprivation stress. Fan X, et al. Chemosphere, 2020 Feb. PMID 31590028
  4. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Espín R, et al. Dis Model Mech, 2013 Mar. PMID 22956347, Free PMC Article
  5. Transcriptome profiling of zebrafish infected with Streptococcus suis. Wu Z, et al. Microb Pathog, 2010 May. PMID 20206250

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in endothelial cells that bypasses caspase-3.
    Title: TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
caspase-2
Names
caspase 2, apoptosis-related cysteine protease
NP_001036160.1
XP_005157976.1
XP_009290451.1
XP_017206813.1
XP_068070011.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042695.1 → NP_001036160.1  caspase-2

    See identical proteins and their annotated locations for NP_001036160.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ812119
    UniProtKB/TrEMBL
    B3DIG1, E7F2V8, Q0PKX3
    Related
    ENSDARP00000148777.1, ENSDART00000186475.1
    Conserved Domains (2) summary
    cd00032
    Location:158 → 428
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08332
    Location:7 → 94
    CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    17550229..17578432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292176.4 → XP_009290451.1  caspase-2 isoform X2

    See identical proteins and their annotated locations for XP_009290451.1

    UniProtKB/TrEMBL
    B3DIG1, E7F2V8, Q0PKX3
    Related
    ENSDARP00000108155.2, ENSDART00000128388.4
    Conserved Domains (2) summary
    cd00032
    Location:158 → 428
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08332
    Location:7 → 94
    CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

  2. XM_005157919.5 → XP_005157976.1  caspase-2 isoform X1

    UniProtKB/TrEMBL
    A0A288CG41, A0A8N7XJ01, F1Q7C2
    Related
    ENSDARP00000105801.3, ENSDART00000122212.4
    Conserved Domains (2) summary
    cd00032
    Location:158 → 430
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08332
    Location:7 → 94
    CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

  3. XM_068213910.1 → XP_068070011.1  caspase-2 isoform X2

  4. XM_017351324.3 → XP_017206813.1  caspase-2 isoform X1

    UniProtKB/TrEMBL
    A0A288CG41, A0A8N7XJ01, F1Q7C2
    Related
    ENSDARP00000115348.2, ENSDART00000137215.3
    Conserved Domains (2) summary
    cd00032
    Location:158 → 430
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08332
    Location:7 → 94
    CARD_CASP2; Caspase activation and recruitment domain of Caspase-2
Nucleotide Protein Strain
Heading Accession and Version

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